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Human DNA Repair Genes

This is an update of the table cited in Wood RD, Mitchell M, & Lindahl T Mutation Research, 2005, in Science, 2001, in the reference book DNA Repair and Mutagenesis, 2nd edition, 2006, and in Nature Reviews Cancer, 2011

This table was last modified by R. Wood and M. Lowery on Wednesday 10th June 2020

Base excision repair (BER)

DNA glycosylases

Other BER and strand break joining factors

Poly (ADP-ribose) polymerase (PARP) enzymes

Direct reversal of damage

Repair of DNA-protein crosslinks

Mismatch excision repair (MMR)

Nucleotide excision repair (NER)

TFIIH

NER-related

Homologous recombination

Fanconi anemia

Non-homologous end-joining

Modulation of nucleotide pools

DNA polymerases (catalytic subunits)

Editing and processing nucleases

Ubiquitination and modification

Chromatin Structure

Genes defective in diseases associated with sensitivity to DNA damaging agents

Other identified genes with known or suspected DNA repair function

Other conserved DNA damage response genes

Related papers

Gene Name (synonyms) linked to Some gene products act in more than one pathway, but each is listed only once below	Activity linked to	Chromosome location linked to	Accession number linked to
Base excision repair (BER)	DNA glycosylases: major altered base released	Top of Page
Other BER and strand break joining factors		Top of Page
Poly(ADP-ribose) polymerase (PARP) enzymes that bind to DNA		Top of Page
Direct reversal of damage	Top of Page
Repair of DNA-protein crosslinks	Top of Page
Mismatch excision repair (MMR)	Top of Page
	Mismatch (MSH2-MSH6) and loop (MSH2-MSH3) recognition , ,
	MutL homologs, forming heterodimer ,
	MutS homologs specialized for meiosis ,
	MutL homologs of unknown function , PMS2L3
Nucleotide excision repair (NER)	(XP = xeroderma pigmentosum)	Top of Page
	Binds DNA distortions , ,
	Complex defective in XP group E ,
	Binds DNA in preincision complex , ,
TFIIH	Catalyzes unwinding in preincision complex	Top of Page
	Kinase subunits of TFIIH , ,
NER-related	Top of Page
	Cockayne syndrome and UV-Sensitive Syndrome; Needed for transcription-coupled NER , ,
Homologous recombination	Top of Page
	Shu subunits, RAD51 recruitment , , ,
	DNA break and crosslink repair ,
	Accessory factors for recombination , ,
	Recruit cohesion during HR ,
	Suppressing end-resection , ,
	Subunits of structure-specific DNA nuclease , ,
	Subunit of SLX1-SLX4 structure-specific nuclease, two identical tandem genes in the human genome ,
Fanconi anemia	Tolerance and repair of DNA crosslinks and other adducts in DNA		Top of Page
	,
	,
Non-homologous end-joining	Top of Page
Modulation of nucleotide pools	Top of Page
DNA polymerases	Top of Page
	Pol delta subunits , , ,
	Pol epsilon subunits , , ,
Editing and processing nucleases	Top of Page
	incision 3' of hypoxanthine and uracil in DNA and inosine in RNA
Ubiquitination and modification	Top of Page
	Ubiquitin-conjugating complex ,
Chromatin Structure and Modification	Top of Page
Genes defective in diseases associated with sensitivity to DNA damaging agents	Top of Page
Other identified genes with known or suspected DNA repair function	Top of Page
Other conserved DNA damage response genes	Top of Page
	subunits of PCNA-like sensor of damaged DNA , ,
	Effector kinases ,
Top of Page

Related Publications:

• Human DNA Repair Genes.

  Wood RD, Mitchell M, Sgouros JG, Lindahl T, Science 291, 1284 (2001)

• Human DNA Repair Genes, 2005

  Wood RD, Mitchell M, Lindahl T, Mutation Res. 577, 275 (2005)