Landmark study maps spatial organization of cancer-associated fibroblasts across cancers
Landmark study maps spatial organization of cancer-associated fibroblasts across cancers
Cancer-associated fibroblasts (CAFs) are essential components of the tumor microenvironment that influence how tumors grow, evade the immune system and respond to therapy. However, their spatial organization and functional diversity are poorly understood. In a pan-cancer spatial multi-omics study, Linghua Wang, M.D., Ph.D., Humam Kadara, Ph.D....
Combination therapy shows no added survival benefit in patients with cervical cancer
Patients with intermediate-risk cervical cancer often receive chemotherapy with radiation therapy after surgery, but the added benefit of...
BCMA-directed CAR T cell therapy is safe in patients with relapsed or refractory multiple myeloma and CNS involvement
Due to the risk of associated neurotoxicities, some clinicians are hesitant to consider B-cell maturation antigen (BCMA)-directed chimeric...
Whole-slide imaging allows real-time remote diagnosis for breast cancer
Pathologists traditionally use light microscopy to evaluate stained frozen sections?of lymph nodes obtained during surgery in patients with breast cancer. To enable pathologists to support the surgeons remotely, researchers led by Savitri Krishnamurthy, M.D., evaluated the use of whole-slide imaging (WSI), a digital pathology tool that allows pathologists to remotely view the frozen sections of lymph nodes in real time at different...
Study provides genomic insights into treatment resistance in SMARCA4-mutant lung cancer
SMARCA4 ¨C a gene that helps in chromatin remodeling ¨C frequently is mutated in lung cancer, leading to immunotherapy?resistance and a...
Phase II study identifies potential biomarkers in HPV-positive anal cancer
Cytotoxic chemotherapy is the standard of care for patients with unresectable and metastatic squamous cell carcinoma of the anal canal ¨C a...
Bioinformatics chatbot can analyze large-scale cancer proteomics data
Comprehensive cancer omics initiatives like The Cancer Genome Atlas (TCGA) provide a wealth of DNA and RNA data, but little is known about...
Combination therapy yields strong long-term overall response rate in newly diagnosed acute myeloid leukemia patients
Intensive chemotherapy remains the standard treatment option for medically fit patients with newly diagnosed acute myeloid leukemia?(AML)....
Study offers insights into evolutionary process driving pancreatic cancer aggressiveness
Pancreatic cancer is hard to treat because of its heterogeneity, a characteristic frequently sustained by the ability of cells to change states...
Researchers identify epigenetic biomarker for breast cancer metastatic relapse
Cancer cells that initiate metastasis at secondary sites often enter a dormant state, allowing them to evade treatment and later reawaken...
Surgery enhances immunotherapy in advanced kidney cancer
Patients with advanced solid tumors are usually ineligible for surgery. However, surgically removing the primary tumor in preclinical models...