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Our laboratory research is directed at using high-throughput profiling techniques to identify candidate predictive biomarkers and potential new therapeutic targets in lung and head and neck cancers. Specific markers of interest which are being further investigated as therapeutic targets include the DNA repair protein PARP1, CHK1 and WEE1 in small cell lung cancer and the tyrosine kinase receptor Axl in non-small cell lung cancer and head and neck cancers. Our laboratory has recently been heavily involved in the lung and head and neck cancer working groups of The Cancer Genome Atlas (TCGA).