Publications
2025
Cell cycle progression of under-replicated cells. Nucleic Acids Res 53(1), 2025. e-Pub 2025. PMID: 39778868; PMCID: PMC11707533.
2024
In vivo CRISPR screens identify Mga as an immunotherapy target in triple-negative breast cancer. Proc Natl Acad Sci U S A. 2024 Sep 24;121(39):e2406325121. doi: 10.1073/pnas.2406325121. Epub 2024 Sep 19. PMID: 39298484; PMCID: PMC11441491.
. Proteomic analysis of ferroptosis pathways reveals a role of CEPT1 in suppressing ferroptosis. Protein Cell. 2024 Sep 1;15(9):686-703. doi: 10.1093/procel/pwae004. PubMed PMID: 38430542; PubMed Central PMCID: PMC11365556.
. Systematic investigation of BRCA1-A, -B, and -C complexes and their functions in DNA damage response and DNA repair. Oncogene. 2024 Aug;43(35):2621-2634. doi: 10.1038/s41388-024-03108-y. Epub 2024 Jul 27. PMID: 39068216.
DePARylation is critical for S phase progression and cell survival. Elife. 2024 Apr 5;12. doi: 10.7554/eLife.89303. PubMed PMID: 38578205; PubMed Central PMCID: PMC10997334.
Genome-wide CRISPR screen reveals the synthetic lethality between BCL2L1 inhibition and radiotherapy. Life Sci Alliance. 2024 Apr;7(4). doi: 10.26508/lsa.202302353. Print 2024 Apr. PubMed PMID: 38316463; PubMed Central PMCID: PMC10844523.
. Mutant p53 gains oncogenic functions through a chromosomal instability-induced cytosolic DNA response. Nat Commun. 2024 Jan 2;15(1):180. doi: 10.1038/s41467-023-44239-2. PMID: 38167338; PMCID: PMC10761733.
2023
. RAD54L2-mediated DNA damage avoidance pathway specifically preserves genome integrity in response to topoisomerase 2 poisons. Sci Adv. 2023 Dec 8;9(49):eadi6681. doi: 10.1126/sciadv.adi6681. Epub 2023 Dec 6. PubMed PMID: 38055811; PubMed Central PMCID: PMC10699775.
. DePARylation is critical for S phase progression and cell survival. Elife. 2024 Apr 5;12:RP89303. doi: 10.7554/eLife.89303. PMID: 38578205; PMCID: PMC10997334.
Multiomics analyses reveal DARS1-AS1/YBX1-controlled posttranscriptional circuits promoting glioblastoma tumorigenesis/radioresistance. Sci Adv. 2023 Aug 4;9(31):eadf3984. doi: 10.1126/sciadv.adf3984. Epub 2023 Aug 4. PMID: 37540752; PMCID: PMC10403220.
. FACS-based genome-wide CRISPR screens define key regulators of DNA damage signaling pathways. Mol Cell. 2023 Aug 3;83(15):2810-2828.e6. doi: 10.1016/j.molcel.2023.07.004. PubMed PMID: 37541219; PubMed Central PMCID: PMC10421629.
Genome-Wide CRISPR Screens Reveal ZATT as a Synthetic Lethal Target of TOP2-Poison Etoposide That Can Act in a TDP2-Independent Pathway. Int J Mol Sci. 2023 Mar 31;24(7):6545. doi: 10.3390/ijms24076545. PMID: 37047518; PMCID: PMC10095316.
Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis. Nat Cell Biol. 2023 Mar;25(3):404-414. doi: 10.1038/s41556-023-01091-2. Epub 2023 Feb 6. PMID: 36747082; PMCID: PMC10027392.
Lysosomal TMEM9-LAMTOR4-controlled mTOR signaling integrity is required for mammary tumorigenesis. Cancer Commun (Lond). 2023 Jan;43(1):159-163. doi: 10.1002/cac2.12382. Epub 2022 Nov 6. PMID: 36336962; PMCID: PMC9859727.
2022
Protocol for establishing a protein-protein interaction network using tandem affinity purification followed by mass spectrometry in mammalian cells. STAR Protoc. 2022 Jul 19;3(3):101569. doi: 10.1016/j.xpro.2022.101569. PMID: 35874475; PMCID: PMC9304681.
CHD1 promotes sensitivity to Aurora kinase inhibitors by suppressing interaction of AURKA with its coactivator TPX2. Cancer Res. 2022 Sep 2;82(17):3088-3101. doi: 10.1158/0008-5472.CAN-22-0631. PMID: 35771632; PMCID: PMC9444962.
. USP7 substrates identified by proteomics analysis reveal the specificity of USP7. Genes Dev. 2022 Sep 1;36(17-18):1016-1030. doi: 10.1101/gad.349848.122. Epub 2022 Oct 27. PMID: 36302555; PMCID: PMC9732911.
TDP1-independent pathways in the process and repair of TOP1-induced DNA damage. Nat Commun. 2022 Jul 22;13(1):4240. doi: 10.1038/s41467-022-31801-7. PMID: 35869071; PMCID: PMC9307636.
ATR-mediated CD47 and PD-L1 up-regulation restricts radiotherapy-induced immune priming and abscopal responses in colorectal cancer. Sci Immunol 7(72):eabl9330, 6/10/2022. e-Pub 6/10/2022. PMID: 35687697; PMCID: PMC9373855.
Integrated screens uncover a cell surface tumor suppressor gene KIRREL involved in Hippo pathway. Proc Natl Acad Sci U S A 119(25):e2121779119, 6/21/2022. e-Pub 6/15/2022. PMID: 35704761; PMCID: PMC9231494.
Genome-wide CRISPR Screens Using Isogenic Cells Reveal Vulnerabilities Conferred by Loss of Tumor Suppressors. Sci Adv 2022 May 13;8(19):eabm6638. doi: 10.1126/sciadv.abm6638. Epub 2022 May 13. PMID: 35559673; PMCID: PMC9106303.
Histone chaperone ASF1 acts with RIF1 to promote DNA end joining in BRCA1-deficient cells. J Biol Chem. 2022 Apr 25;298(6):101979. doi: 10.1016/j.jbc.2022.101979. Epub ahead of print. PMID: 35472331; PMCID: PMC9127577.
2021
. Low-density-lipoprotein-receptor-related protein 1 mediates Notch pathway activation. Dev Cell. 2021 Oct 25;56(20):2902-2919.e8. doi: 10.1016/j.devcel.2021.09.015. Epub 2021 Oct 8. PMID: 34626540.
. Genetic vulnerabilities upon inhibition of DNA damage response. Nucleic Acids Res. 2021 Aug 20;49(14):8214-8231. doi: 10.1093/nar/gkab643. PMID: 34320214; PMCID: PMC8373146.
Interactomes of SARS-CoV-2 and human coronaviruses reveal host factors potentially affecting pathogenesis. EMBO J. 2021 Sep 1;40(17):e107776. doi: 10.15252/embj.2021107776. Epub 2021 Jul 26. PMID: 34232536; PMCID: PMC8447597.
Genome-wide CRISPR screens reveal cyclin C as synthetic survival target of BRCA2. Nucleic Acids Res. 2021 Jul 21;49(13):7476-7491. doi: 10.1093/nar/gkab540. PMID: 34197614; PMCID: PMC8287926.
Ubiquitylation in DNA double-strand break repair. DNA Repair (Amst). 2021 Jul;103:103129. doi: 10.1016/j.dnarep.2021.103129. Epub 2021 May 7. PMID: 33990032; PMCID: PMC8207832.
Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance. Nat Commun. 2021 Jun 29;12(1):4033. doi: 10.1038/s41467-021-24298-z. PMID: 34188037; PMCID: PMC8242032.
. mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation. Nat Commun. 2021 Mar 11;12(1):1589. doi: 10.1038/s41467-021-21841-w. PMID: 33707434; PMCID: PMC7952727.
PAF remodels the DREAM complex to bypass cell quiescence and promote lung tumorigenesis. Mol Cell. 2021 Apr 15;81(8):1698-1714.e6. doi: 10.1016/j.molcel.2021.02.001. Epub 2021 Feb 23. PMID: 33626321; PMCID: PMC8052288.
Mass spectrometry-based protein?protein interaction techniques and their applications in studies of DNA damage repair. J Zhejiang Univ Sci B. 2021 Jan 15;22(1):1-20. doi: 10.1631/jzus.B2000356. PMID: 33448183; PMCID: PMC7818012.
2020
DNA polymerase ¦É compensates for Fanconi anemia pathway deficiency by countering DNA replication stress. Proc Natl Acad Sci U S A. 2020 Dec 29;117(52):33436-33445. doi: 10.1073/pnas.2008821117. Epub 2020 Dec 21. PMID: 33376220; PMCID: PMC7777187.
A Surge of DNA Damage Links Transcriptional Reprogramming and Hematopoietic Deficit in Fanconi Anemia. Mol Cell. 2020 Dec 17;80(6):1013-1024.e6. doi: 10.1016/j.molcel.2020.11.040. PMID: 33338401; PMCID: PMC8600940.
Selective Labeling and Identification of the Tumor Cell Proteome of Pancreatic Cancer In Vivo. J Proteome Res. 2021 Jan 1;20(1):858-866. doi: 10.1021/acs.jproteome.0c00666. Epub 2020 Dec 8. PMID: 33289385; PMCID: PMC8718109.
Proteome-wide Analysis Reveals Substrates of E3 Ligase RNF146 Targeted for Degradation. Mol Cell Proteomics. 2020 Dec;19(12):2015-2029. doi: 10.1074/mcp.RA120.002290. Epub 2020 Sep 21. PMID: 32958691; PMCID: PMC7710139.
Biological and clinical aspects of HPV-related cancers. Cancer Biol Med. 2020 Nov 15;17(4):864-878. doi: 10.20892/j.issn.2095-3941.2020.0370. Epub 2020 Dec 15. PMID: 33299640; PMCID: PMC7721094.
Extracellular signal-regulated kinases associate with and phosphorylate DHPS to promote cell proliferation. Oncogenesis. 2020 Sep 28;9(9):85. doi: 10.1038/s41389-020-00271-1. PMID: 32989218; PMCID: PMC7522278.
C17orf53 is identified as a novel gene involved in inter-strand crosslink repair. DNA Repair (Amst). 2020 Nov;95:102946. doi: 10.1016/j.dnarep.2020.102946. Epub 2020 Aug 15. PMID: 32853826; PMCID: PMC7669678.
FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function. Cell Rep. 2020 Aug 11;32(6):108018. doi: 10.1016/j.celrep.2020.108018. PMID: 32783940; PMCID: PMC7458625.
ATR inhibition potentiates ionizing radiation-induced interferon response via cytosolic nucleic acid-sensing pathways. EMBO J. 2020 Jul 15;39(14):e104036. doi: 10.15252/embj.2019104036. Epub 2020 Jun 2. PMID: 32484965; PMCID: PMC7361286.
Phosphoproteomics Analysis Reveals a Potential Role of CHK1 in Regulation of Innate Immunity through IRF3. J Proteome Res. 2020 Jun 5;19(6):2264-2277. doi: 10.1021/acs.jproteome.9b00829. Epub 2020 May 8. PMID: 32314919.
HMCES safeguards replication from oxidative stress and ensures error-free repair. EMBO Rep. 2020 Jun 4;21(6):e49123. doi: 10.15252/embr.201949123. Epub 2020 Apr 19. PMID: 32307824; PMCID: PMC7271331.
. Genome-wide CRISPR screen uncovers a synergistic effect of combining Haspin and Aurora kinase B inhibition. Oncogene. 2020 May;39(21):4312-4322. doi: 10.1038/s41388-020-1296-2. Epub 2020 Apr 16. PMID: 32300176; PMCID: PMC7291820.
CRISPR/CAS9-based DNA damage response screens reveal gene-drug interactions. DNA Repair (Amst). 2020 Mar;87:102803. doi: 10.1016/j.dnarep.2020.102803. Epub 2020 Jan 16. PubMed PMID: 31991288; PubMed Central PMCID: PMC7034363
The ARK Assay Is a Sensitive and Versatile Method for the Global Detection of DNA-Protein Crosslinks. Cell Rep. 2020 Jan 28;30(4):1235-1245.e4. doi:10.1016/j.celrep.2019.12.067. PubMed PMID: 31995761; PubMed Central PMCID:PMC7069250
DNA-protein cross-link repair: what do we know now? Cell Biosci. 2020 Jan 7;10:3. doi: 10.1186/s13578-019-0366-z. eCollection 2020. Review. PubMed PMID: 31921408; PubMed Central PMCID: PMC6945406
AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair. Mol Cell Proteomics. 2020 Mar;19(3):467-477. doi: 10.1074/mcp.RA119.001794. Epub 2020 Jan 3. PubMed PMID:31900314; PubMed Central PMCID: PMC7050103
2019
Elucidation of WW domain ligand binding specificities in the Hippo pathway reveals STXBP4 as YAP inhibitor. EMBO J. 2020 Jan 2;39(1):e102406. doi: 10.15252/embj.2019102406. Epub 2019 Nov 29. PubMed PMID:31782549; PubMed Central PMCID:PMC6939200.
SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair. Nucleic Acids Res. 2019 Nov 4;47(19):10181-10201. doi: 10.1093/nar/gkz769. PubMed PMID: 31495888; PubMed Central PMCID: PMC6821277.
. Nuclear receptors regulate alternative lengthening of telomeres through a novel noncanonical FANCD2 pathway. Sci Adv. 2019 Oct 9;5(10):eaax6366. doi: 10.1126/sciadv.aax6366. eCollection 2019 Oct. PubMed PMID: 31633027; PubMed Central PMCID: PMC6785246.
Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling. Nat Commun. 2019 Sep 25;10(1):4363. doi: 10.1038/s41467-019-12377-1. PubMed PMID: 31554794; PubMed Central PMCID: PMC6761205.
Remodeling of Interstrand Crosslink Proximal Replisomes Is Dependent on ATR, FANCM, and FANCD2. Cell Rep. 2019 May 7;27(6):1794-1808.e5. doi: 10.1016/j.celrep.2019.04.032. PubMed PMID: 31067464; PubMed Central PMCID: PMC6676478.
Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition. Oncogene. 2019 Apr;38(14):2451-2463. doi: 10.1038/s41388-018-0606-4. Epub 2018 Dec 7. PubMed PMID:30532030; PubMed Central PMCID:PMC6450769.
Global phosphoproteomic analysis reveals ARMC10 as an AMPK substrate that regulates mitochondrial dynamics. Nat Commun 10(1):104, 1/2019. e-Pub 1/2019. PMCID: PMC6328551.
Chen Z, Lei C, Wang C, Li N, Srivastava M, Tang M, Zhang H, Choi JM, Jung SY, Qin J, Chen J. Global phosphoproteomic analysis reveals ARMC10 as an AMPK substrate that regulates mitochondrial dynamics. Nat Commun 10(1):104, 1/2019. e-Pub 1/2019. PMCID: PMC6328551.
2018
Delineating WWOX Protein Interactome by Tandem Affinity Purification-Mass Spectrometry: Identification of Top Interactors and Key Metabolic Pathways Involved. Front Oncol 8:591, 2018. e-Pub 12/2018. PMCID: PMC6300487.
Replisome Dynamics and Their Functional Relevance upon DNA Damage through the PCNA Interactome. Cell Rep 25(13):3869-3883.e4, 12/2018. PMCID: PMC6364303.
TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/¦Â-catenin signalling. Nat Cell Biol 20(12):1421-1433, 12/2018. e-Pub 10/2018. PMCID: PMC6261670.
Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via ¦Â-catenin. Nat Cell Biol 20(11):1303-1314, 11/2018. e-Pub 10/2018. PMCID: PMC6261439.
Mitosis-specific MRN complex promotes a mitotic signaling cascade to regulate spindle dynamics and chromosome segregation. Proc Natl Acad Sci U S A 115(43):E10079-E10088, 10/2018. e-Pub 10/2018. PMCID: PMC6205471.
BAP1 links metabolic regulation of ferroptosis to tumour suppression. Nat Cell Biol 20(10):1181-1192, 10/2018. e-Pub 9/2018. PMCID: PMC6170713.
ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer. Cell Rep. 2018 Apr 17;23(3):823-837. doi: 10.1016/j.celrep.2018.03.078. PubMed PMID: 29669287; PubMed Central PMCID: PMC5933875.
. CDK16 Phosphorylates and Degrades p53 to Promote Radioresistance and Predicts Prognosis in Lung Cancer. Theranostics 8(3):650-662, 2018. e-Pub 1/2018. PMCID: PMC5771083.
S6K1 phosphorylation-dependent degradation of Mxi1 by ¦Â-Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer. Theranostics 8(5):1286-1300, 2018. e-Pub 2/2018. PMCID: PMC5835936.
2017
TRIP12 as a mediator of human papillomavirus/p16-related radiation enhancement effects. Oncogene. 2017 Feb 9;36(6):820-828. doi: 10.1038/onc.2016.250. Epub 2016 Jul 18. PubMed PMID: 27425591; PubMed Central PMCID: PMC5434711.
CRISPR/Cas9-Coupled Affinity Purification/Mass Spectrometry Analysis Revealed a Novel Role of Neurofibromin in mTOR Signaling. Mol Cell Proteomics 16(4):594-607, 4/2017. e-Pub 2/2017. PMCID: PMC5383781.
The p53-binding Protein 1-Tudor Interacting Repair Regulator Complex Participates in the DNA Damage Response. J Biol Chem 292(16):6461-6467, 4/2017. e-Pub 2/2017. PMCID: PMC5399100.
Proteomic Analysis of the Human Tankyrase Protein Interaction Network Reveals Its Role in Pexophagy. Cell Rep 20(3):737-749, 7/2017. PMID: 28723574.
A transcriptional coregulator, SPIN-DOC, attenuates the coactivator activity of Spindlin1. J Biol Chem 292(51):20808-20817, 12/2017. e-Pub 10/2017. PMCID: PMC5743059.
Constitutive role of the Fanconi anemia D2 gene in the replication stress response. J Biol Chem 292(49):20184-20195, 12/2017. e-Pub 10/2017. PMCID: PMC5724005.
53BP1: keep an eye on merotely. Oncotarget 8(30):48527-48528, 7/2017. PMCID: PMC5564702.
Recent progress in mass spectrometry proteomics for biomedical research. Sci China Life Sci 60(10):1093-1113, 10/2017. e-Pub 10/2017. PMID: 29039124.
. TRIP12 as a mediator of human papillomavirus/p16-related radiation enhancement effects. Oncogene. 2017 Feb 9;36(6):820-828. doi: 10.1038/onc.2016.250. Epub 2016 Jul 18. PubMed PMID: 27425591; PubMed Central PMCID: PMC5434711.
2016
H1 provides the missing link. Cell Res 26(1):5-6, 1/2016. e-Pub 11/2015. PMCID: PMC4816129.
SLFN11 inhibits checkpoint maintenance and homologous recombination repair. EMBO Rep 17(1):94-109, 1/2016. e-Pub 12/2015. PMCID: PMC4718411.
PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness. Nat Commun 7:10633, 2/2016. e-Pub 2/2016. PMCID: PMC4743006.
LIG4 mediates Wnt signaling-induced radioresistance. Nat Commun 7:10994, 3/2016. e-Pub 3/2016. PMCID: PMC4820809.
LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. Nat Cell Biol 18(4):431-42, 4/2016. e-Pub 3/2016. PMCID: PMC4814347.
PARP Inhibition Suppresses Growth of EGFR-Mutant Cancers by Targeting Nuclear PKM2. Cell Rep 15(4):843-856, 4/2016. e-Pub 4/2016. PMCID: PMC5063668.
Proteomic Analysis Reveals a Novel Mutator S (MutS) Partner Involved in Mismatch Repair Pathway. Mol Cell Proteomics 15(4):1299-308, 4/2016. PMCID: PMC4824856.
System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes. Mol Cell 62(1):121-36, 4/2016. e-Pub 3/2016. PMCID: PMC4988125.
FOXR2 Interacts with MYC to Promote Its Transcriptional Activities and Tumorigenesis. Cell Rep 16(2):487-97, 7/2016. e-Pub 6/2016. PMCID: PMC4946253.
Defining the protein-protein interaction network of the human protein tyrosine phosphatase family. Mol Cell Proteomics 15(9):3030-44, 9/2016. e-Pub 7/2016. PMCID: PMC5013315.
LATS1 and LATS2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ. Hepatology 64(5):1757-1772, 11/2016. e-Pub 9/2016. PMCID: PMC5863546.
Identification of KIAA1199 as a Biomarker for Pancreatic Intraepithelial Neoplasia. Sci Rep 6:38273, 12/2016. e-Pub 12/2016. PMCID: PMC5138641.
RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response. Curr Biol 26(24):3257-3268, 12/2016. e-Pub 11/2016. PMCID: PMC5173396.
novoBreak: local assembly for breakpoint detection in cancer genomes. Nat Methods 14(1):65-67, 1/2017. e-Pub 11/2016. PMCID: PMC5199621.
Loss of the transforming growth factor-¦Â effector ¦Â2-Spectrin promotes genomic instability. Hepatology 65(2):678-693, 2/2017. e-Pub 12/2016. PMCID: PMC5432427.
2015
Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth. Genes Dev 29(2):157-70, 1/2015. e-Pub 12/2014. PMCID: PMC4298135.
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Mol Syst Biol 11(1):775, 1/2015. e-Pub 1/2015. PMCID: PMC4332150.
FOXKs Promote Wnt/¦Â-Catenin Signaling by Translocating DVL into the Nucleus. Dev Cell 32(6):707-18, 3/2015. PMCID: PMC4374128.
TopBP1 stabilizes BLM protein to suppress sister chromatid exchange. Mol Cell 57(6):955-6, 3/2015. PMID: 25794614.
UHRF1 contributes to DNA damage repair as a lesion recognition factor and nuclease scaffold. Cell Rep 10(12):1957-66, 3/2015. e-Pub 3/2015. PMCID: PMC4748712.
AMPK modulates Hippo pathway activity to regulate energy homeostasis. Nat Cell Biol 17(4):490-9, 4/2015. e-Pub 3/2015. PMCID: PMC4380807.
Aberrant Expression of proPTPRN2 in Cancer Cells Confers Resistance to Apoptosis. Cancer Res 75(9):1846-58, 5/2015. e-Pub 4/2015. PMCID: PMC4417433.
Energy crisis and the Hippo pathway. Cell Cycle. 2015;14(13):1995-6. doi: 10.1080/15384101.2015.1046788. Epub 2015 May 5. PubMed PMID:25942485; PubMed Central PMCID:PMC4614403.
REV7 counteracts DNA double-strand break resection and affects PARP inhibition. Nature 521(7553):541-4, 5/2015. e-Pub 3/2015. PMCID: PMC4671316.
Tankyrase Inhibitors Target YAP by Stabilizing Angiomotin Family Proteins. Cell Rep 13(3):524-32, 10/2015. e-Pub 10/2015. PMCID: PMC4618173.
. Cell cycle-dependent inhibition of 53BP1 signaling by BRCA1. Cell Discov 1:15019, 2015. e-Pub 8/2015. PMCID: PMC4860855.
2014
Defining the protein-protein interaction network of the human Hippo pathway. Mol Cell Proteomics 13(1):119-31, 1/2014. e-Pub 10/2013. PMCID: PMC3879608.
P53-participated cellular and molecular responses to irradiation are cell differentiation-determined in murine intestinal epithelium. Arch Biochem Biophys 542C:21-27, 1/2014. e-Pub 12/2013. PMID: 24315958.
ADP-ribosylation: activation, recognition, and removal. Mol Cells. 2014 Jan;37(1):9-16. doi: 10.14348/molcells.2014.2245. Epub 2014 Jan 27. Review. PubMed PMID:24552704; PubMed Central PMCID:PMC3907000.
Fam118B, a newly identified component of Cajal bodies, is required for Cajal body formation, snRNP biogenesis and cell viability. J Cell Sci 127(Pt 9):2029-39, 5/2014. e-Pub 2/2014. PMCID: PMCPMC4004977.
Modularized functions of the fanconi anemia core complex. Cell Rep 7(6):1849-57, 6/2014. e-Pub 6/2014. PMCID: PMC4157997.
ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nat Cell Biol 16(9):864-75, 9/2014. e-Pub 8/2014. PMCID: PMC4150825.
Mitochondrial reactive oxygen species are scavenged by Cockayne syndrome B protein in human fibroblasts without nuclear DNA damage. Proc Natl Acad Sci U S A 111(37):13487-92, 9/2014. e-Pub 8/2014. PMCID: PMC4169934.
Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1. J Cell Biol 206(7):877-94, 9/2014. PMCID: PMC4178966.
Proteomic Analysis of the Human Cyclin-dependent Kinase Family Reveals a Novel CDK5 Complex Involved in Cell Growth and Migration. Mol Cell Proteomics 13(11):2986-3000, 11/2014. e-Pub 8/2014. PMCID: PMC4223486.
miR-205 acts as a tumour radiosensitizer by targeting ZEB1 and Ubc13. Nat Commun 5:5671, 12/2014. e-Pub 12/2014. PMCID: PMC4377070.
PTIP associates with Artemis to dictate DNA repair pathway choice. Genes Dev 28(24):2693-8, 12/2014. PMCID: PMC4265673.
From pathways to networks: connecting dots by establishing protein-protein interaction networks in signaling pathways using affinity purification and mass spectrometry. Proteomics. 2015 Jan;15(2-3):188-202. doi: 10.1002/pmic.201400147. Epub 2014 Oct 18. Review. PubMed PMID:25137225; PubMed Central PMCID:PMC4482759.
2013
PNUTS functions as a proto-oncogene by sequestering PTEN. Cancer Res 73(1):205-14, 1/2013. e-Pub 11/2012. PMCID: PMC3538077.
The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1. EMBO J 32(1):126-39, 1/2013. e-Pub 11/2012. PMCID: PMC3545304.
MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis. J Cell Sci 126(Pt 3):825-37, 2/2013. e-Pub 12/2012. PMCID: PMC3619811.
PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis. J Biol Chem 288(5):3174-83, 2/2013. e-Pub 12/2012. PMCID: PMC3561539.
Alpha Thalassemia/Mental Retardation Syndrome X-linked Gene Product ATRX Is Required for Proper Replication Restart and Cellular Resistance to Replication Stress. J Biol Chem 288(9):6342-50, 3/2013. e-Pub 1/2013. PMCID: PMC3585069.
. FANCM and FAAP24 Maintain Genome Stability via Cooperative as Well as Unique Functions. Mol Cell 49(5):997-1009, 3/2013. e-Pub 1/2013. PMCID: PMC3595374.
RIF1 counteracts BRCA1-mediated end resection during DNA repair. J Biol Chem 288(16):11135-43, 4/2013. e-Pub 3/2013. PMCID: PMC3630874.
BRCA1 is a negative modulator of the PRC2 complex. EMBO J 32(11):1584-97, 5/2013. e-Pub 4/2013. PMCID: PMC3671259.
FIGNL1-containing protein complex is required for efficient homologous recombination repair. Proc Natl Acad Sci U S A 110(26):10640-5, 6/2013. e-Pub 6/2013. PMCID: PMC3696823.
Structural insights into recognition of MDC1 by TopBP1 in DNA replication checkpoint control. Structure 21(8):1450-9, 8/2013. e-Pub 7/2013. PMCID: PMC3760280.
Structure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage response. Cell Res 23(10):1215-28, 10/2013. e-Pub 9/2013. PMCID: PMC3790240.
Whole-genome screening identifies proteins localized to distinct nuclear bodies. J Cell Biol 203(1):149-64, 10/2013. PMCID: PMC3798253.
Akt regulates TPP1 homodimerization and telomere protection. Aging Cell 12(6):1091-9, 12/2013. e-Pub 8/2013. PMCID: PMC4051222.
Deubiquitylation and stabilization of PTEN by USP13. Nat Cell Biol 15(12):1486-94, 12/2013. e-Pub 11/2013. PMCID: PMC3951854.
TopBP1 Controls BLM Protein Level to Maintain Genome Stability. Mol Cell 52(5):667-78, 12/2013. e-Pub 11/2013. PMCID: PMC3880544.
DNA damage tolerance: a double-edged sword guarding the genome. Transl Cancer Res 2(3):107-129, 2013. PMCID: PMC3779140.
2012
The E3 ligase RNF8 regulates KU80 removal and NHEJ repair. Nat Struct Mol Biol 19(2):201-6, 1/2012. e-Pub 1/2012. PMCID: PMC3888515.
RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage. DNA Repair (Amst) 11(2):131-8, 2/2012. e-Pub 10/2011. PMCID: PMC3779126.
Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair. Proc Natl Acad Sci U S A 109(12):4491-6, 3/2012. e-Pub 3/2012. PMCID: PMC3311328.
RAP80 protein is important for genomic stability and is required for stabilizing BRCA1-A complex at DNA damage sites in vivo. J Biol Chem 287(27):22919-26, 6/2012. e-Pub 4/2012. PMCID: PMC3391110.
The HARP-like Domain-Containing Protein AH2/ZRANB3 Binds to PCNA and Participates in Cellular Response to Replication Stress. Mol Cell 47(3):410-21, 8/2012. e-Pub 6/2012. PMCID: PMC3601832.
PTPN14 is required for the density-dependent control of YAP1. Genes Dev 26(17):1959-71, 9/2012. PMCID: PMC3435498.
KIAA1530 is recruited by cockayne syndrome complementation group protein A (CSA) to participate in transcription-coupled repair (TCR). J Biol Chem 287(42):35118-26, 10/2012. e-Pub 8/2012. PMCID: PMC3471710.
PCNA-binding protein C1orf124 is a regulator of translesion synthesis. J Biol Chem 287(41):34225-33, 10/2012. e-Pub 8/2012. PMCID: PMC3464530.
ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells. J Neurooncol 110(3):349-57, 12/2012. e-Pub 10/2012. PMID: 23054561.
RNF8 regulates active epigenetic modifications and escape gene activation from inactive sex chromosomes in post-meiotic spermatids. Genes Dev 26(24):2737-48, 12/2012. PMCID: PMC3533078.
Alteration/deficiency in activation 3 (ADA3): Regulator of DNA repair and genome stability. Cell Cycle. 2012 Dec 15;11(24):4496. doi: 10.4161/cc.22934. Epub 2012 Dec 6. PubMed PMID:23222062; PubMed Central PMCID:PMC3562290.
2011
Angiomotin-like proteins associate with and negatively regulate YAP1. J Biol Chem 286(6):4364-70, 2/2011. e-Pub 12/2010. PMCID: PMC3039387.
Molecular basis of BACH1/FANCJ recognition by TopBP1 in DNA replication checkpoint control. J Biol Chem 286(6):4292-301, 2/2011. e-Pub 12/2010. PMCID: PMC3039391.
The Role of the Human SWI5-MEI5 Complex in Homologous Recombination Repair. J Biol Chem 286(11):9888-93, 3/2011. e-Pub 1/2011. PMCID: PMC3059048.
MDC1 collaborates with TopBP1 in DNA replication checkpoint control. J Cell Biol 193(2):267-73, 4/2011. e-Pub 4/2011. PMCID: PMC3080258.
MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells. Genes Dev 25(9):959-71, 5/2011. PMCID: PMC3084029.
. Critical Roles of Ring Finger Protein RNF8 in Replication Stress Responses. J Biol Chem 286(25):22355-61, 6/2011. e-Pub 5/2011. PMCID: PMC3121383.
E3 Ligase RFWD3 Participates in Replication Checkpoint Control. J Biol Chem 286(25):22308-13, 6/2011. e-Pub 4/2011. PMCID: PMC3121377.
SET Nuclear Oncogene Associates with Microcephalin/MCPH1 and Regulates Chromosome Condensation. J Biol Chem 286(24):21393-400, 6/2011. e-Pub 4/2011. PMCID: PMC3122199.
The HARP domain dictates the annealing helicase activity of HARP/SMARCAL1. EMBO Rep 12(6):574-80, 6/2011. e-Pub 4/2011. PMCID: PMC3128281.
WWP2 is an E3 ubiquitin ligase for PTEN. Nat Cell Biol 13(6):728-33, 6/2011. e-Pub 5/2011. PMID: 21532586.
hSWS1¡¤SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair. J Biol Chem 286(48):41758-66, 12/2011. e-Pub 9/2011. PMCID: PMC3308884.
The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection. Nat Struct Mol Biol 18(12):1400-7, 12/2011. e-Pub 11/2011. PMCID: PMC3657743.
2010
MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX. J Biol Chem 285(2):1097-104, 1/2010. e-Pub 11/2009. PMCID: PMC2801237
Assembly of checkpoint and repair machineries at DNA damage sites. Trends Biochem Sci. 2010 Feb;35(2):101-8. doi: 10.1016/j.tibs.2009.09.001. Epub 2009 Oct 28. Review. PubMed PMID: 19875294; PubMed Central PMCID: PMC3209802.
BRCA1 and its toolbox for the maintenance of genome integrity. Nat Rev Mol Cell Biol. 2010 Feb;11(2):138-48. doi: 10.1038/nrm2831. Epub 2009 Dec 23. Review. PubMed PMID:20029420; PubMed Central PMCID:PMC3899800.
A pocket on the surface of the N-terminal BRCT domain of Mcph1 is required to prevent abnormal chromosome condensation. J Mol Biol 395(5):908-15, 2/2010. e-Pub 11/2009. PMCID: PMC2813331.
BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control. Mol Cell 37(3):438-46, 2/2010. PMCID: PMC3695484.
Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. J Clin Invest 120(2):545-58, 2/2010. e-Pub 1/2010. PMCID: PMC2810074.
CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response. Nucleic Acids Res 38(5):1489-503, 3/2010. e-Pub 12/2009. PMCID: PMC2836575.
Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1. Mol Cell 37(6):854-64, 3/2010. PMCID: PMC3695488.
Characterization of the DOT1L network: implications of diverse roles for DOT1L. Protein J 29(3):213-23, 4/2010. PMID: 20431927.
SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60. J Biol Chem 285(15):11458-64, 4/2010. e-Pub 1/2010. PMCID: PMC2857024.
Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8. J Exp Med 207(5):973-81, 5/2010. e-Pub 4/2010. PMCID: PMC2867275.
ATM Creates a veil of transcriptional silence. Cell. 2010 Jun 11;141(6):924-6. doi: 10.1016/j.cell.2010.05.035. PubMed PMID:20550929.
Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. Mol Cell 38(6):864-78, 6/2010. PMID: 20620956.
SON is a spliceosome-associated factor required for mitotic progression. Cell Cycle 9(13). e-Pub 7/2010. PMID: 20581448.
FAN1 Acts with FANCI-FANCD2 to Promote DNA Interstrand Cross-Link Repair. Science 329(5992):693-6, 8/2010. e-Pub 7/2010. PMID: 20671156.
Focus on histone variant H2AX: to be or not to be. FEBS Lett. 2010 Sep 10;584(17):3717-24. doi: 10.1016/j.febslet.2010.05.021. Epub 2010 May 21. Review. PubMed PMID:20493860; PubMed Central PMCID:PMC3695482.
Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2. Nat Struct Mol Biol 17(10):1255-9, 10/2010. e-Pub 9/2010. PMCID: PMC2950913.
The Lys 63-specific deubiquitinating enzyme BRCC36 is regulated by two scaffold proteins localizing in different subcellular compartments. J Biol Chem 285(40):30982-8, 10/2010. e-Pub 7/2010. PMCID: PMC2945589.
RAD18 lives a double life: Its implication in DNA double-strand break repair. DNA Repair (Amst). 2010 Dec 10;9(12):1241-8. doi: 10.1016/j.dnarep.2010.09.016. PubMed PMID: 20971043.
2009
Histone ubiquitination associates with BRCA1-Dependent DNA Damage Response. Mol Cell Biol 29(3):849-860, 2/2009. e-Pub 11/2008. PMCID: PMC2630672.
Topoisomerase IIalpha controls the decatenation checkpoint. Nat Cell Biol 11(2):204-10, 2/2009. e-Pub 12/2008. PMCID: PMC2712943.
Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage. J Biol Chem 284(11):7284-93, 3/2009. e-Pub 1/2009. PMCID: PMC2652327.
MERIT40 facilitates BRCA1 localization and DNA damage repair. Genes Dev 23(6):719-28, 3/2009. e-Pub 3/2009. PMCID: PMC2661609.
is an integral component of the BRCA complex required for homologous recombination repair. Proc Natl Acad Sci U S A 106(17):7155-60, 4/2009. e-Pub 4/2009. PMCID: PMC2678481.
Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase. Nat Cell Biol 11(4):409-19, 4/2009. e-Pub 3/2009. PMCID: PMC2754075.
Functional interaction between Chfr and Kif22 controls genomic stability. J Biol Chem 284(19):12998-3003, 5/2009. e-Pub 3/2009. PMCID: PMC2676032.
RAD18 transmits DNA damage signalling to elicit homologous recombination repair. Nat Cell Biol 11(5):592-603, 5/2009. e-Pub 4/2009. PMCID: PMC2743127.
PALB2 Regulates Recombinational Repair through Chromatin Association and Oligomerization. J Biol Chem 284(27):18302-10, 7/2009. e-Pub 5/2009. PMCID: PMC2709360.
A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Mol Cell 35(4):534-41, 8/2009. PMID: 19716796.
MRG15 is a novel PALB2-interacting factor involved in homologous recombination. J Biol Chem 284(32):21127-31, 8/2009. e-Pub 6/2009. PMCID: PMC2755835.
SOSS complexes participate in the maintenance of genomic stability. Mol Cell 35(3):384-93, 8/2009. PMCID: PMC2756616.
Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice. J Clin Invest 119(9):2714-24, 9/2009. e-Pub 8/2009. PMCID: PMC2735912.
p30 DBC is a potential regulator of tumorigenesis. Cell Cycle. 2009 Sep 15;8(18):2932-5. doi: 10.4161/cc.8.18.9473. Epub 2009 Sep 8. Review. PubMed PMID:19657230; PubMed Central PMCID:PMC2777512.
The annealing helicase HARP protects stalled replication forks. Genes Dev 23(20):2394-9, 10/2009. e-Pub 9/2009. PMCID: PMC2764499.
Interactions between DBC1 and SIRT 1 are deregulated in breast cancer cells. Cell Cycle 8(22):3784-5, 11/2009. e-Pub 11/2009. PMID: 19855164.
N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair. J Biol Chem 284(46):31746-52, 11/2009. e-Pub 9/2009. PMCID: PMC2797245.
The ubiquitin pathway: an emerging drug target in cancer therapy. Eur J Pharmacol 625(1-3):199-205, 12/2009. e-Pub 10/2009. PMID: 19835866.
2008
The DNA damage response pathways: at the crossroad of protein modifications. Cell Res. 2008 Jan;18(1):8-16. doi: 10.1038/cr.2007.109. Review. PubMed PMID:18087291.
DBC1 is a negative regulator of SIRT1. Nature 451(7178):583-6, 1/2008. PMID: 18235501.
Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication. J Biol Chem 283(17):11073-7, 4/2008. e-Pub 3/2008. PMCID: PMC2431066.
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. Mol Cell Biol 28(8):2825-39, 4/2008. e-Pub 2/2008. PMCID: PMC2293113.
. Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis. J Cell Biol 181(5):727-35, 6/2008. e-Pub 5/2008. PMCID: PMC2396806.
New players in the BRCA1-mediated DNA damage responsive pathway. Mol Cells. 2008 Jun 30;25(4):457-61. Epub 2008 Apr 24. Review. PubMed PMID:18443409; PubMed Central PMCID:PMC3873642.
VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation. Oncogene 27(29):4056-64, 7/2008. e-Pub 3/2008. PMID: 18332868.
Generation and characterization of novel monoclonal antibodies against human aurora-A. Hybridoma (Larchmt) 27(4):313-8, 8/2008. PMCID: PMC3186696.
MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks. Proc Natl Acad Sci U S A 105(32):11200-5, 8/2008. e-Pub 8/2008. PMCID: PMC2516250.
Structure of a second BRCT domain identified in the nijmegen breakage syndrome protein Nbs1 and its function in an MDC1-dependent localization of Nbs1 to DNA damage sites. J Mol Biol 381(2):361-72, 8/2008. e-Pub 6/2008. PMCID: PMC2574983.
Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression. Nat Cell Biol 10(9):1076-82, 9/2008. PMCID: PMC2882053.
Microcephalin/MCPH1 associates with the Condensin II complex to function in homologous recombination repair. J Biol Chem 283(43):29586-92, 10/2008. e-Pub 8/2008. PMCID: PMC2570891.
Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly. Mol Cell Biol 28(19):6104-12, 10/2008. e-Pub 8/2008. PMCID: PMC2547017.
Aurora A is essential for early embryonic development and tumor suppression. J Biol Chem 283(46):31785-31790, 11/2008. e-Pub 9/2008. PMCID: PMC2581543.
Polo-like kinase 1 is essential for early embryonic development and tumor suppression. Mol Cell Biol 28(22):6870-6, 11/2008. e-Pub 9/2008. PMCID: PMC2573299.
. When loose ends finally meet. Nat Struct Mol Biol. 2008 Dec;15(12):1241-2. doi: 10.1038/nsmb1208-1241. PubMed PMID:19050718; NIHMSID:NIHMS103841.
2007
Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response. Science 316(5828):1202-5, 5/2007. PMID: 17525342.
CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response. Nat Struct Mol Biol 14(8):710-5, 8/2007. e-Pub 7/2007. PMID: 17643122.
Differences in DNA double strand breaks repair in male germ cell types: lessons learned from a differential expression of Mdc1 and 53BP1. DNA Repair (Amst) 6(9):1243-54, 9/2007. e-Pub 3/2007. PMID: 17376750.
c-Myc interacts with TRF1/PIN2 and regulates telomere length. Biochem Biophys Res Commun 362(4):842-7, 11/2007. e-Pub 8/2007. PMCID: PMC2047600.
MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage. J Biol Chem 282(48):35416-23, 11/2007. e-Pub 10/2007. PMCID: PMC2128040.
. RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell 131(5):901-14, 11/2007. e-Pub 11/2007. PMCID: PMC2149842.
Distinct Roles of Chromatin-Associated Proteins MDC1 and 53BP1 in Mammalian Double-Strand Break Repair. Mol Cell 28(6):1045-1057, 12/2007. PMCID: PMC2275782.
2006
H2AX prevents DNA breaks from Progressing to Chromosome breaks and Translocations. Mol Cell 21(2):201-214, 1/2006. PMID: 16427010.
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell 21(2):187-200, 2006. PMID: 16427009.
Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature 440(7080):105-9, 3/2006. e-Pub 1/2006. PMID: 16400328.
Signaling networks controlled by the MRN complex and MDC1 during early DNA damage responses. Mol Carcinog. 2006 Jun;45(6):403-8. doi: 10.1002/mc.20221. Review. PubMed PMID:16691596.
BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP. Genes Dev 20(13):1721-6, 7/2006. PMCID: PMC1522068.
Chk1 is required to maintain claspin stability. Oncogene 25(30):4165-71, 7/2006. e-Pub 2/2006. PMID: 16501606.
Characterization of CHEK2 mutations in prostate cancer. Hum Mutat 27(8):742-7, 8/2006. PMID: 16835864.
CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage. Science 314(5797):294-7, 10/2006. PMID: 17038621.
Cellular senescence and DNA repair. Exp Cell Res. 2006 Aug 15;312(14):2641-6. doi: 10.1016/j.yexcr.2006.06.009. Epub 2006 Jun 20. Review. PubMed PMID:16893723.
The role of Vpr in HIV-1 disease progression is independent of its G2 arrest induction function. Cell Cycle 5(19):2275-80, 10/2006. e-Pub 10/2006. PMID: 16969134.
Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function. J Biol Chem 281(44):33276-33282, 11/2006. e-Pub 9/2006. PMID: 16963448.
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell 127(7):1361-73, 12/2006. PMCID: PMC1804291.
The tandem BRCT domain of 53BP1 is not required for its repair function. J Biol Chem 281(50):38472-7, 12/2006. e-Pub 10/2006. PMCID: PMC1853281.
2005-1993
The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis. J Biol Chem 280(7):5733-9, 2/2005. e-Pub 11/2004. PMID: 15545273.
Planelles V. ATR and GADD45alpha mediate HIV-1 Vpr-induced apoptosis. Cell Death Differ 12(4):326-334, 4/2005. PMID: 15650754.
Chfr is required for tumor suppression and Aurora A regulation. Nat Genet 37(4):401-6, 4/2005. e-Pub 3/2005. PMID: 15793587.
Fanconi anemia complementation group D2 (FANCD2) functions independently of BRCA2- and RAD51-associated homologous recombination in response to DNA damage. J Biol Chem 280(15):14877-83, 4/2005. e-Pub 1/2005. PMID: 15671039.
. BRCA1 participates in DNA decatenation. Nat Struct Mol Biol 12(7):589-93, 7/2005. e-Pub 6/2005. PMID: 15965487.
Genomic instability in laminopathy-based premature aging. Nat Med 11(7):780-785, 7/2005. e-Pub 6/2005. PMID: 15980864.
53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice. Mol Cell Biol 25(22):10079-86, 11/2005. PMCID: PMC1280262.
Mammalian DNA damage response pathway. Adv Exp Med Biol. 2005;570:425-55. doi: 10.1007/1-4020-3764-3_15. Review. PubMed PMID:18727510.
The mitotic checkpoint in cancer and aging: what have mice taught us?. Curr Opin Cell Biol. 2005 Dec;17(6):583-9. doi: 10.1016/j.ceb.2005.09.011. Epub 2005 Oct 13. Review. PubMed PMID:16226453.
Activation of the ATR pathway by human immunodeficiency virus type 1 Vpr involves its direct binding to chromatin in vivo. J Virol 79(24):15443-51, 12/2005. PMCID: PMC1315993.
Gemcitabine-induced activation of checkpoint signaling pathways that affect tumor cell survival. Mol Pharmacol 68(6):1636-44, 12/2005. e-Pub 8/2005. PMID: 16126823.
Human TopBP1 ensures genome integrity during normal S phase. Mol Cell Biol 25(24):10907-15, 12/2005. PMCID: PMC1316943.
UV-induced ataxia-telangiectasia-mutated and Rad3-related (ATR) activation requires replication stress. J Biol Chem 279(11):9677-80, 3/2004. e-Pub 1/2004. PMID: 14742437.
53BP1 is required for class switch recombination. J Cell Biol 165(4):459-64, 5/2004. PMCID: PMC2172356.
Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains. Structure 12(7):1137-46, 7/2004. PMID: 15242590.
Early events in the DNA damage response. Curr Top Dev Biol. 2004;63:1-35. doi: 10.1016/S0070-2153(04)63001-8. Review. PubMed PMID:15536012.
Claspin, a regulator of Chk1 in DNA replication stress pathway. DNA Repair (Amst). 2004 Aug-Sep;3(8-9):1033-7. doi: 10.1016/j.dnarep.2004.03.001. Review. PubMed PMID:15279790.
Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J Cell Biol 166(6):801-813, 9/2004. PMCID: PMC2172115.
DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains. Mol Cell Biol 24(21):9478-86, 11/2004. PMCID: PMC522253.
Human immunodeficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and Hus 1 and induces nuclear BRCA1 and gamma-H2AX focus formation. Mol Cell Biol 24(21):9286-9294, 11/2004. PMCID: PMC522272.
MDC1 regulates DNA-PK autophosphorylation in response to DNA damage. J Biol Chem 279(45):46359-62, 11/2004. e-Pub 9/2004. PMID: 15377652.
MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature 421(6926):957-61, 2/2003. PMID: 12607004.
Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control. J Biol Chem 278(16):13599-602, 4/2003. e-Pub 2/2003. PMID: 12611903.
p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Mol Cell Biol 23(7):2556-63, 4/2003. PMCID: PMC150747.
Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX. J Biol Chem 278(22):19579-82, 5/2003. e-Pub 4/2003. PMID: 12697768.
BRCA proteins and DNA damage checkpoints. Front Biosci. 2003 May 1;8:s718-21. doi: 10.2741/1127. Review. PubMed PMID:12700125.
Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint. Cancer Res 63(12):3049-3053, 6/2003. PMID: 12810625.
Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment. J Biol Chem 278(32):30051-6, 8/2003. e-Pub 5/2003. PMID: 12766176.
Human claspin is required for replication checkpoint control. J Biol Chem 278(32):30057-62, 8/2003. e-Pub 5/2003. PMID: 12766152.
Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis. J Biol Chem 278(38):36163-8, 9/2003. e-Pub 7/2003. PMID: 12855706.
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Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains. J Biol Chem 278(52):52914-8, 12/2003. e-Pub 10/2003. PMID: 14578343.
Characterization of tumor-associated Chk2 mutations. J Biol Chem 276(4):2971-4, 1/2001. e-Pub 10/2000. PMID: 11053450.
. Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways. J Cell Biol 153(3):613-20, 4/2001. PMCID: PMC2190566.
Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development. Proc Natl Acad Sci U S A 98(21):12078-83, 10/2001. e-Pub 10/2001. PMCID: PMC59770.
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J Biol Chem 276(51):47759-62, 12/2001. e-Pub 10/2001. PMID: 11673449.
Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks. J Biol Chem 276(51):47755-47758, 12/2001. e-Pub 10/2001. PMID: 11668173.
A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival. Mol Cell Biol 22(2):555-66, 1/2002. PMCID: PMC139754.
The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity. J Biol Chem 277(10):7849-56, 3/2002. e-Pub 12/2001. PMID: 11751867.
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat Cell Biol 4(12):993-7, 12/2002. PMID: 12447390.
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Independence of R/M/N focus formation and the presence of intact BRCA1. Science 289(5476):11-11a, 7/2000. PMID: 10928918.
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. Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas. Nat Genet 21(2):236-240, 2/1999. PMID: 9988281.
. BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway. Cancer Res 59(7 Suppl):1752s-1756s, 4/1999. PMID: 10197592.
Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase. Mol Cell Biol 18(5):2758-67, 5/1998. PMCID: PMC110655.
Evidence that partial unwrapping of DNA from nucleosomes facilitates the binding of heat shock factor following DNA replication in yeast. J Biol Chem 273(32):20463-72, 8/1998. PMID: 9685401.
Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol Cell 2(3):317-28, 9/1998. PMID: 9774970.
Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88(2):265-75, 1/1997. PMID: 9008167.
Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell 90(3):425-35, 8/1997. PMID: 9267023.
A 39 amino acid fragment of the cell cycle regulator p21 is sufficient to bind PCNA and partially inhibit DNA replication in vivo. Nucleic Acids Res 24(9):1727-33, 5/1996. PMCID: PMC145832.
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p21Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex. Proc Natl Acad Sci U S A 93(21):11597-602, 10/1996. PMCID: PMC38103.
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