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Soft tissue sarcomas are a diverse group of rare cancers affecting both adults and children and are generally associated with poor prognosis. Surgery is the mainstay of treatment and the only potentially curative treatment for patients with localized soft tissue sarcoma. Unfortunately, many patients develop sarcoma recurrence after surgery and/or present with metastatic disease, and we currently lack effective systemic therapies for many patients with sarcoma.  

The Keung Lab is focused on understanding the molecular pathogenesis and tumor immune microenvironment of three of the most common types of soft tissue sarcoma in adults:

• Undifferentiated pleomorphic sarcoma
• Liposarcoma
• Leiomyosarcoma

Using experimental (wet lab) and computational (dry lab) approaches and learning from biospecimens contributed by patients receiving care at MD Anderson, our goals are to:

1. Expand our understanding of fundamental soft tissue sarcoma biology
2. Identify novel therapeutic vulnerabilities and targets
3. Develop innovative treatment strategies
4. Translate these strategies to patients through clinical trials
5. Ultimately improve outcomes for our patients who have these challenging cancers

Our tools and models include:

• Clinical observations and patient samples
• Patient-derived cell lines
• Advanced spatial profiling