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Peer-Reviewed Articles

1. . Cleavage-defective Topoisomerase I mutants sharply increase G-quadruplex-associated genomic instability. Microb Cell 9(3):52-68, 2022. e-Pub 2022. PMID: 35291312.
2. . X-ray scattering reveals disordered linkers and dynamic interfaces in complexes and mechanisms for DNA double-strand break repair impacting cell and cancer biology. Protein Sci 30(9):1735-1756, 2021. e-Pub 2021. PMID: 34056803.
3. . Visualizing functional dynamicity in the DNA-dependent protein kinase holoenzyme DNA-PK complex by integrating SAXS with cryo-EM. Prog Biophys Mol Biol S0079-6107(20):30091-2, 2021. e-Pub 2020. PMID: 32966823.
4. . Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors. Prog Biophys Mol Biol 163:171-186, 2021. e-Pub 2021. PMID: 33636189.
5. . GRB2 enforces homology-directed repair initiation by MRE11. Sci Adv 7(32), 2021. e-Pub 2021. PMID: 34348893.
6. . EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart. Mol Cell 81(14):2989-3006.e9, 2021. e-Pub 2021. PMID: 34197737.
7. . A first-in-class Polymerase Theta Inhibitor selectively targets Homologous-Recombination-Deficient Tumors. Nat Cancer 2(6):598-610, 2021. e-Pub 2021. PMID: 34179826.
8. . Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin. Nucleic Acids Res 49(1):221-243, 2021. PMID: 33300026.
9. . Function and Molecular Mechanism of the DNA Damage Response in Immunity and Cancer Immunotherapy. Front Immunol 12:797880, 2021. e-Pub 2021. PMID: 34970273.
10. . Decoding Cancer Variants of Unknown Significance for Helicase-Nuclease-RPA Complexes Orchestrating DNA Repair During Transcription and Replication. Front Mol Biosci 8:791792, 2021. e-Pub 2021. PMID: 34966786.
11. . An efficient chemical screening method for structure-based inhibitors to nucleic acid enzymes targeting the DNA repair-replication interface and SARS CoV-2. Methods Enzymol 661:407-431, 2021. e-Pub 2021. PMID: 34776222.
12. . Mechanism Of Efficient Double-Strand Break Repair By a Long Non-Coding RNA. Nucleic Acids Res 48(19):10953-10972, 2020. PMID: 33045735.
13. . PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis. Nat Cell Biol 22(10):1264-1275, 2020. e-Pub 2020. PMID: 32929201.
14. . XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cells. NAR Cancer 2(3):zcaa013, 2020. e-Pub 2020. PMID: 32776008.
15. . Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations. Proc Natl Acad Sci U S A 117(25):14127-14138, 2020. e-Pub 2020. PMID: 32522879.
16. . Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death. Nat Commun 10(1):5654, 2019. e-Pub 2019. PMID: 31827085.
17. . DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities. Mol Cell 53(1):7-18, 2014. e-Pub 2013. PMID: 24316220.
18. . Accurate assessment of mass, models and resolution by small-angle scattering. Nature 496(7446):477-81, 2013. PMID: 23619693.
19. . Vitamin E Enhances Cancer Immunotherapy by Reinvigorating Dendritic Cells via Targeting Checkpoint SHP1. Cancer Discov. e-Pub 2022. PMID: 35420681.