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2024

 Type I conventional dendritic cells facilitate immunotherapy in pancreatic cancer. 2024 Jun 28;384(6703):eadh4567. doi: 10.1126/science.adh4567. Epub 2024 Jun 28.PMID: 38935717

 STAT3 protects hematopoietic stem cells by preventing activation of a deleterious autocrine type-I interferon response. Leukemia. 2024 May;38(5):1143-1155. doi: 10.1038/s41375-024-02218-6. Epub 2024 Mar 11.PMID: 38467768

2023

. Targeting PD-L2-RGMb overcomes microbiome-related immunotherapy resistance. Nature. 2023 May;617(7960):377-385. doi: 10.1038/s41586-023-06026-3. Epub 2023 May 3. PMID: 37138075.

. Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration. J Exp Med. 2023 Feb 6;220(2):e20221333. doi: 10.1084/jem.20221333. Epub 2022 Nov 11. PMID: 36367776. 

. Microbiome influencers of checkpoint blockade-associated toxicity. J Exp Med. 2023 Mar 6;220(3):e20220948. doi: 10.1084/jem.20220948. Epub 2023 Jan 9. PMID: 36622383.

. Microbiome alteration via fecal microbiota transplantation is effective for refractory immune checkpoint inhibitor-induced colitis. Sci Transl Med. 2023 Jun 14;15(700):eabq4006. doi: 10.1126/scitranslmed.abq4006. Epub 2023 Jun 14. PMID: 37315113.

. Antigen-presenting type-I conventional dendritic cells facilitate curative checkpoint blockade immunotherapy in pancreatic cancer. bioRxiv. 2023 Mar 6:2023.03.05.531191. doi: 10.1101/2023.03.05.531191. Preprint. PMID: 36945457.

. STAT3 protects HSCs from intrinsic interferon signaling and loss of long-term blood-forming activity. bioRxiv. 2023 Feb 11:2023.02.10.528069. doi: 10.1101/2023.02.10.528069. Preprint. PMID: 3679826

. Neutrophil elastase remodels mammary tumors to facilitate lung metastasis. Mol Cancer Ther. 2023 Oct 5. doi: 10.1158/1535-7163.MCT-23-0414. Online ahead of print. PMID: 37796181

2022

. Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration. J Exp Med. 220(2):e20221333. Epub 2022. PMID:3636776

. STAT3 inhibits autocrine IFN signaling in type 1 conventional dendritic cells. J Immunol. 209(7):1286-1299. 2022. PMID:36038291

. Regulation and function of Id2 in plasmacytoid dendritic cells. Mol Immunol. 148:6-17. 2022. PMID:35640521

. Microbiome influencers of checkpoint blockade-associated toxicity. J Exp Med. 2022, in press.

. Targeting IL-1b as an immunepreventive and therapeutic modality for K-ras-mutant lung cancer. JCI Insight. 7(11):e157788. 2022. PMID:35471938.

. Immune landscape of a genetically engineered murine model of glioma compared with human glioma. JCI Insight. 7(12):e148990. 2022. PMID:35653194.

. Doxorubicin-induced cardiotoxicity is mediated by neutrophils through release of neutrophil elastase. Front Oncol. 12:947604. 2022. PMID:36033503.

. Checkpoint inhibitors as immunotherapy for fungal infections: Promises, challenges, and unanswered questions. Front. Front Immunol. 2022 Oct 25;13:1018202. doi: 10.3389/fimmu.2022.1018202. eCollection 2022. PMID: 36389687.

2021

. Gut microbiota signatures are associated with toxicity to combined CTLA-4 and PD-1 blockade. Nat Med 27(8):1432-1441, 8/2021. e-Pub 7/2021. PMID: 34239137.

 Tonic interferon restricts pathogenic IL-17-driven inflammatory disease via balancing the microbiome. Elife 10, 8/2021. e-Pub 8/2021. PMCID: PMC8376249

. Dietary fiber and probiotics influence the gut microbiome and melanoma immunotherapy response. Science. 2021 Dec 24;374(6575):1632-1640. doi: 10.1126/science.aaz7015. Epub 2021 Dec 23. PMID: 34941392

2020

 STAT3 Inhibits CD103+ cDC1 Vaccine Efficacy in Murine Breast Cancer. Cancers. 2020 Jan; 12(1):128. doi: 10.3390/cancers12010128. PubMed PMID:31947933; PubMedCentral PMCID: PMC7017236.

 Histone deacetylase inhibitors and IL21 cooperate to reprogram human effector CD8+ T cells to memory T cells. Cancer Immunol Res. 2020 Mar 25; doi: 10.1158/2326-6066.CIR-19-0619. [Epub ahead of print]. PubMed PMID: 32213626.

. Vaccine efficacy against primary and metastatic cancer with in vitro-generated CD103+ conventional dendritic cells. J Immunother Cancer. 2020 Apr;8(1):e000474;  doi: 10.1136/jitc-2019-000474. PubMed PMID: 32273347. 

. Interplay between estrogen and Stat3/NF-¦ÊB driven immunomodulation in lung cancer. Carcinogenesis. e-Pub 6/2020. PMID: 32603404.

2019

 PPARD and Interferon Gamma Promote Transformation of Gastric Progenitor Cells and Tumorigenesis in Mice. Gastroenterology. 2019 Jul;157(1):163-178. doi: 10.1053/j.gastro.2019.03.018. Epub 2019 Mar 15. PubMed PMID: 30885780.

 Preventing abnormal NF-¦ÊB activation and autoimmunity by Otub1-mediated p100 stabilization. Cell Res. 2019 Jun;29(6):474-485. doi: 10.1038/s41422-019-0174-3. Epub 2019 May 13. PubMed PMID: 31086255.

 FGL2 promotes tumor progression in the CNS by suppressing CD103+ dendritic cell differentiation. Nat Commun. 2019 Jan 25;10(1):448. doi: 10.1038/s41467-018-08271-x. PubMed PMID: 30683885.

 Molecular regulation of dendritic cell development and function in homeostasis,  inflammation, and cancer. Mol Immunol. 2019 Jun;110:24-39. doi:10.1016/j.molimm.2018.01.014. Epub 2018 Mar 15. PubMed PMID: 29549977; PubMed Central PMCID: PMC6139080.

CXCR5+CD8+ T cells are a distinct functional subset with an antitumor activity. Leukemia. 2019 Apr 25;. doi: 10.1038/s41375-019-0464-2. [Epub ahead of print] PubMed PMID: 31028278; NIHMSID:NIHMS1523597.

Combined inhibition of STAT3 and DNA repair in palbociclib-resistant ER-positive breast cancer. Clin Cancer Res. 2019 Mar 13;. doi: 10.1158/1078-0432.CCR-18-3274. [Epub ahead of print] PubMed PMID: 30867218; NIHMSID:NIHMS1524284.

. Introduction to the Special Issue: The tumor microenvironment and molecular regulation of innate immune cells. Mol Immunol. 2019 Jun;110:1-2. doi: 10.1016/j.molimm.2018.10.009. Epub 2018 Oct 11. PMID: 30318379.

2018

 Genetic rescue of lineage-balanced blood cell production reveals a crucial role for STAT3 antiinflammatory activity in hematopoiesis. Proc Natl Acad Sci USA 115(10):E2311-E2319, 3/2018. e-Pub 2/2018. PMCID: PMC5878002.

 Molecular regulation of dendritic cell development and function in homeostasis, inflammation, and cancer. Mol Immunol. e-Pub 3/2018. PMID: 29549977.

 Macrophage conditioned medium promotes colorectal cancer stem cell phenotype via the hedgehog signaling pathway. PLoS One 13(1):e0190070, 2018. e-Pub 1/2018. PMCID: PMC5749743.

. Genetic rescue of lineage-balanced blood cell production reveals a crucial role for STAT3 antiinflammatory activity in hematopoiesis. Proc Natl Acad Sci USA. 2018 Mar 6;115(10):E2311-E2319. doi: 10.1073/pnas.1713889115. Epub 2018 Feb 20.

. Sex specific function of epithelial STAT3 signaling in pathogenesis of K-ras mutant lung cancer. Nat Commun. 2018 Nov 2;9(1):4589. doi: 10.1038/s41467-018-07042-y. PMID: 30389925 

. Role of the Fractalkine Receptor in CNS Autoimmune Inflammation: New Approach Utilizing a Mouse Model Expressing the Human CX3CR1I249/M280 Variant. Front Cell Neurosci. 2018 Oct 17;12:365. doi: 10.3389/fncel.2018.00365. eCollection 2018. PMID: 30386211 

2017

. MicroRNA-22 controls interferon alpha production and erythroid maturation in response to infectious stress in mice. Exp Hematol 56:7-15, 2017. e-Pub 2017. PMID: 28911907.

. The kinase TBK1 functions in dendritic cells to regulate T cell homeostasis, autoimmunity, and antitumor immunity. J Exp Med 214(5):1493-1507, 2017. e-Pub 2017. PMID: 28356390.

. The histone deacetylase inhibitor valproic acid inhibits NKG2D expression in natural killer cells through suppression of STAT3 and HDAC3. Sci Rep 7:45266, 2017. e-Pub 2017. PMID: 28338101.

2016

. Loss of c-Kit and bone marrow failure upon conditional removal of the GATA-2 C-terminal zinc finger domain in adult mice. Eur J Haematol 97(3):261-70, 2016. e-Pub 2016. PMID: 26660446.

. Bypassing STAT3-mediated inhibition of the transcriptional regulator ID2 improves the antitumor efficacy of dendritic cells. Sci Signal 9(447):ra94, 2016. e-Pub 2016. PMID: 27678219.

. IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras-Mutant Lung Cancer. Cancer Res 76(11):3189-99, 2016. e-Pub 2016. PMID: 27197187.

. STAT3 Signaling in Immunity. Cytokine Growth Factor Rev. 2016 Oct;31:1-15. doi: 10.1016/j.cytogfr.2016.05.001. Epub 2016 May 9. Review. PMID:27185365. PMCID:PMC5050093.

2015

. Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-¦Ã Production via the Generation of Reactive Oxygen Species. Cell Rep 12(7):1120-32, 2015. e-Pub 2015. PMID: 26257170.

. 15-Lipoxygenase-1 suppression of colitis-associated colon cancer through inhibition of the IL-6/STAT3 signaling pathway. FASEB J 29(6):2359-70, 2015. e-Pub 2015. PMID: 25713055.

2014

. STAT3 restrains RANK- and TLR4-mediated signalling by suppressing expression of the E2 ubiquitin-conjugating enzyme Ubc13. Nat Commun 5:5798, 2014. e-Pub 2014. PMID: 25503582.

. Innate immune regulation by STAT-mediated transcriptional mechanisms. Immunol Rev. 2014 Sep;261(1):84-101. doi: 10.1111/imr.12198. PMID: 25123278.