Publications
Du C, Guan X, Yan J. (2022) Two-pore channel blockade by phosphoinositide kinase inhibitors YM201636 and PI-103 determined by a histidine residue near pore-entrance. bioRxiv, DOI:
Chen G, Li Q, Yan J. The leucine-rich repeat domains of BK channel auxiliary ¦Ã subunits regulate their expression, trafficking, and channel-modulation functions. Journal of Biological Chemistry (2022) In press DOI:
Shah KR, Guan X, Yan J. (2022) Structural and functional coupling of calcium-activated BK channels and calcium-permeable channels within nanodomain signaling complexes. Frontiers in Physiology 12:796540 PMID:
Zhang J, Guan X, Shah K, Yan J. (2021) Lsm12 is an NAADP receptor and a two-pore channel regulatory protein required for calcium mobilization from acidic organelles. Nature Communications 12(1):4739 PMID: DOI:
Zhou MH, Chen SR, Wang L, Huang Y, Deng M, Zhang J, Zhang J, Chen H, Yan J, Pan HL. (2021) Protein Kinase C-Mediated Phosphorylation and ¦Á2¦Ä-1 Interdependently Regulate NMDA Receptor Trafficking and Activity. Journal of Neuroscience 41(30):6415-6429 PMID:
Vouga AG, Rockman ME, Yan J, Jacobson MA, Rothberg BS. State-dependent inhibition of BK channels by the opioid agonist loperamide. (2021) Journal of General Physiology 153(9). PMCID: PMC8352719. PMID:
Zhang J, Guan X, Li Q, Meredith AL, Pan HL, Yan J. (2018) Glutamate-activated BK channel complexes formed with NMDA receptors. Proceedings of the National Academy of Sciences of the United States of America 115(38):E9006-E9014
Li Q, Li Y, Wei H, Pan HM, Vouga AG, Rothberg BS, Wu Y, Yan J. (2018) Molecular determinants of Ca2+ sensitivity at the intersubunit interface of the BK channel gating ring. Scientific Reports. 8(1): 509. PMID: .
Erasso D, Tender GC, Li Q, Yan J, Culicchia F, Abdi S, Cui J. (2018) The effects of agrin isoforms on diabetic neuropathic pain in a rat streptozotocin model. Anesthesia & Analgesia 127(4):1051-1057. PMID: .
Xin G, Li Q, Yan J. (2017) Relationship between auxiliary gamma subunits and mallotoxin on BK channel modulation. Scientific Reports 7: 42240. PMCID: .
Kshatri AS, Li Q, Yan J, Large RJ, Sergeant GP, McHale NG, Thornbury KD, Hollywood MA. (2017) Differential efficacy of GoSlo-SR compounds on BK¦Á and BK¦Á¦Ã1-4 channels. Channels (Austin) 11(1):66-78, PMCID: .
Yan J, Li Q, Aldrich RW. (2016) Closed-state-coupled C-type inactivation in BK channels. Proceedings of the National Academy of Sciences of the United States of America 113(25):6991-6. PMID:
Li Q, Yan J. (2016) Modulation of BK channel function by auxiliary beta and gamma subunits. International Review of Neurobiology 128:51-90. PMID:
Li Q, Xin G, Yen K, Zhang J, Yan J. (2016) The single transmembrane segment determines the modulatory function of the BK channel auxiliary ¦Ã subunit. Journal of General Physiology 147(4):337-51. PMID:
Li Y, Adamek P, Zhang H, Tatsui CE, Rhines LD, Mrozkova P, Li Q, Kosturakis AK, Cassidy RM, Harrison DS, Cata JP, Sapire K, Zhang H, Kennamer-Chapman RM, Jawad AB, Ghetti A, Yan J, Palecek J, Dougherty PM. (2015) The cancer chemotherapeutic paclitaxel increases human and rodent sensory neuron responses to TRPV1 by activation of TLR4. Journal of Neuroscience 35(39):13487-500, PMID:
Li Q, Fan F, Kwak HR, Yan J. (2015) Molecular basis for differential modulation of BK channel voltage-dependent gating by auxiliary ¦Ã subunits. Journal of General Physiology 145(6):543-54. PMID:
Zhang J, Yan J (2014) Regulation of BK channels by auxiliary ¦Ã subunits. Frontiers in Physiology 5:401. PMCID:
Chen X, Yan J, Aldrich RW (2014) BK channel opening involves side-chain reorientation of multiple deep-pore residues. Proceedings of the National Academy of Sciences of the United States of America 111(1):E79-88. PMID:
Zhang X, Tanaka K, Yan J, Li J, Peng D, Jiang Y, Yang Z, Barton MC, Wen H, Shi X (2013) Regulation of estrogen receptor ¦Á by histone methyltransferase SMYD2-mediated protein methylation. Proceedings of the National Academy of Sciences of the United States of America 110 (43):17284-9. PMID:
Yan J and Aldrich RW (2012) BK potassium channel modulation by leucine-rich repeat-containing proteins. Proceedings of the National Academy of Sciences of the United States of America 109(20):7917-7922. PMID:
Yan J, Aldrich RW (2010) LRRC26 auxiliary protein allows BK channel activation at resting voltage without calcium. Nature 466(7305):513-516. PMID:
Yan J, Olsen JV, Park KS, Li W, Bildl W, Schulte U, Aldrich RW, Fakler B, Trimmer JS (2008) Profiling the phospho-status of the BKCa channel a subunit in rat brain reveals unexpected patterns and complexity. Molecular & Cellular Proteomics 7(11):2188-2198. PMID:
Yan J, Dashdorj N, Baniulis D, Yamashita E, Savikhin S, Cramer WA (2008) On the structural role of the aromatic residue environment of the chlorophyll a in the cytochrome b6f complex. Biochemistry 47(12):3654-3661. PMID:
Yan J, Kurisu G, Cramer WA (2006) Intraprotein transfer of the quinone analogue inhibitor 2,5-dibromo-3-methyl-6-isopropyl-p-benzoquinone in the cytochrome b6f complex. Proceedings of the National Academy of Sciences of the United States of America 103(1):69¨C74. PMID:
Cramer WA, Zhang H, Yan J, Kurisu G, Smith JL (2006) Transmembrane traffic in the cytochrome b6f complex. Annual Review of Biochemistry 75:769-790. PMID:
Cramer WA, Yan J, Zhang H, Kurisu G, Smith JL (2005) Structure of the cytochrome b6f complex: new prosthetic groups, Q-space, and the "hors d'oeuvres hypothesis" for assembly of the complex. Photosynthesis Research 85(1):133-144. PMID:
Adams KL, Tsoi S, Yan J, Durbin SM, Ramdas AK, Cramer WA, Sturhahn W, Ercan Alp E, Schulz C (2006) Fe vibrational spectroscopy of myoglobin and cytochrome f. Journal of Physical Chemistry B 110(1):530-536. PMID:
Kim H, Dashdorj N, Zhang H, Yan J, Cramer WA, Savikhin S (2005) An anomalous distance dependence of intra-protein chlorophyll-carotenoid triplet energy transfer. Biophysical Journal 89(4):28-30. PMID:
Dashdorj N, Zhang H, Kim H, Yan J, Cramer WA, Savikhin S (2005) The single chlorophyll a molecule in the cytochrome b6f complex: unusual optical properties protect the complex against singlet oxygen. Biophysical Journal 88(6):4178-4187 PMID:
Yan J and Cramer WA (2004) Molecular control of a bimodal distribution of quinone- analogue inhibitor binding sites in the cytochrome b6f complex. Journal of Molecular Biology 344(2):481-493. PMID:
Cramer WA, Zhang H, Yan J, Kurisu G, Smith JL (2004) Evolution of photosynthesis: Time independent structure of the cytochrome b6f complex of oxygenic photosynthesis. Biochemistry 43(20):5921-5929. PMID:
Smith JL, Zhang H, Yan J, Kurisu G, Cramer WA (2004) Cytochrome bc complexes: a common core of structure and function surrounded by diversity in the outlying provinces. Current Opinion in Structural Biology 14(4):432-439. PMID:
Yan J, Cramer WA (2003) Functional insensitivity of the cytochrome b6f complex to structure changes in the hinge region of the Rieske iron-sulfur protein. Journal of Biological Chemistry 278(23):20925-20933. PMID:
Yan J, Liu Y, Mao D, Li L, Kuang T (2001) The presence of 9-cis-b-carotene in cytochrome b6f complex from spinach. Biochimica et Biophysica Acta - Bioenergetics 1506(3):182-188. PMID:
Li X, Li Z, Yan J, Li H, Han B, Hu K, Wang A (2001) Investigation of structural change of purple membrane in storage by transmission electron microscope and atomic force microscope. Chinese Science Bulletin 46:1753-1756.
Yan J, Mao D, Chen H, Kuang T, Li B (2000) Effects of membrane lipids on the electron transfer activity of cytochrome b6f complex from spinach. Acta Bot Sin 42:1267-1270.