- Research Resources
- Excellence in Science
- Excellence in Science FY24
Fiscal Year 2024 Awardees
Research is a cornerstone of MD Anderson¡¯s quest to end cancer. The Excellence in Science program is the online showcase for the Wall of Science, our quarterly program for honoring outstanding primary research selected from among publications in top journals by MD Anderson¡¯s world-renowned scientists.
Quarter 1 (September¨CNovember 2023)
John Heymach
New England Journal of Medicine
Perioperative Durvalumab for Resectable Non-Small-Cell Lung Cancer
Professor and Chair, Thoracic/Head and Neck Medical Oncology
David Bruton, Jr. Chair
Xiaoyin Lu and Pawel Mazur
Xiaoyin Lu, Ph.D.
Postdoctoral Fellow
Experimental Radiation Oncology
Assistant Professor
Experimental Radiation Oncology
Nature Biomedical Engineering
Multiplexed transcriptomic profiling of the fate of human CAR T cells in vivo via genetic barcoding with shielded small nucleotides
Krishnan Mahadevan, Raghu Kalluri and Anirban Maitra
Cancer Cell
KRASG12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells
Krishnan Mahadevan,?M.B.B.S., Ph.D.
Postdoctoral Fellow
Cancer Biology
Chair and Professor, Cancer Biology
Frederick F. Becker Distinguished University Chair
Professor
Pathology and Translational Molecular Pathology
Marcelo Negrao
Assistant Professor
Thoracic/Head and Neck Medical Oncology
Journal of Clinical Oncology
Intracranial Efficacy of Adagrasib in Patients From the KRYSTAL-1 Trial With KRASG12C-Mutated Non-Small-Cell Lung Cancer Who Have Untreated CNS Metastases
Marcelo Negrao and Ferdinandos Skoulidis
Cancer Discovery
Comutations and KRASG12C Inhibitor Efficacy in Advanced NSCLC
Assistant Professor
Thoracic/Head and Neck Medical Oncology
Associate Professor
Thoracic/Head and Neck Medical Oncology
Arlene Siefker-Radtke
Professor
Genitourinary Medical Oncology
New England Journal of Medicine
Erdafitinib or Chemotherapy in Advanced or Metastatic Urothelial Carcinoma
Kaile Wang and Nick Navin
Cell
Archival single-cell genomics reveals persistent subclones during DCIS progression
Kaile Wang, Ph.D.
Assistant Professor
Systems Biology
Chair and Professor
Systems Biology
The Grady F. Saunders, Ph.D. Distinguished Professorship for Molecular Biology
Michael Wang
Professor
Lymphoma-Myeloma
Puddin Clarke Endowed Professor
Journal of Clinical Oncology
Pirtobrutinib in Covalent Bruton Tyrosine Kinase Inhibitor Pretreated Mantle-Cell Lymphoma
Quarter 2 (December 2023¨CFebruary 2024)
Vidhi Chandra and Florencia McAllister
Cancer Cell
Gut epithelial Interleukin-17 receptor A signaling can modulate distant tumors growth through microbial regulation
Vidhi Chandra, Ph.D.
Postdoctoral Fellow
Genetics
Associate Professor
Genetics & GI Medical Oncology
Lauren Colbert and Ann Klopp
Assistant Professor
Department of Radiation Oncology
Professor
Department of Radiation Oncology
Cancer Cell
Tumor-resident Lactobacillus iners confer chemoradiation resistance through lactate-induced metabolic rewiring
Eyal Gottlieb
Cell Metabolism
Serine synthesis via reversed SHMT2 activity drives glycine depletion and acetaminophen hepatotoxicity in MASLD
Eyal?Gottlieb, Ph.D.
Professor
Cancer Biology
Xue Hao
Assistant Professor
Experimental Therapeutics
Nature
TXNRD1 drives the innate immune response in senescent cells with implications for age-associated inflammation
John Heymach
Nature Medicine
Biomarker-directed targeted therapy plus durvalumab in advanced non-small-cell lung cancer: a phase 2 umbrella trial
Professor and Chair, Thoracic/Head and Neck Medical Oncology
David Bruton, Jr. Chair
Shubham Pant
Professor
Gastrointestinal (GI) Medical Oncology
Nature Medicine
Lymph-node-targeted, mKRAS-specific amphiphile vaccine in pancreatic and colorectal cancer: the phase 1 AMPLIFY-201 trial
Katy Rezvani and David Marin
Nature Cancer
Safety, efficacy and determinants of response of allogeneic CD19-specific CAR-NK cells in CD19+ B cell tumors: a phase 1/2 trial
Sally Cooper Murray Chair in Cancer Research
Chief, Section of Cell Therapy
Medical Director GMP and Cell Therapy Facility
Professor, Stem Cell Transplantation and Cellular Therapy
Professor
Stem Cell Transplantation
Haoqiang Ying
Associate Professor
Molecular and Cellular Oncology
Science
Modulation of the proteostasis network promotes tumor resistance to oncogenic KRAS inhibitors
Quarter 3 (March¨CMay 2024)
Paul Cinciripini
Journal of the American Medical Association
Smoking Cessation After Initial Treatment Failure With Varenicline or Nicotine Replacement: A Randomized Clinical Trial
Professor and Chair, Behavioral Science
Margaret & Ben Love Chair in Clinical Cancer Care in honor of Dr. Charles A. LeMaistre
Director, Tobacco Treatment Program
Michael Green
Associate Professor, Lymphoma & Myeloma and Genomic Medicine
Vice Chair, Lymphoma Research
Laboratory Director, Lymphoma Tissue Bank
Director, Lymphoid Malignancies Biology Program
Cancer Cell
SMARCA4 is a haploinsufficient B cell lymphoma tumor suppressor that fine-tunes centrocyte cell fate decisions
Simon Heeke, Lauren Byers and John Heymach
Cancer Cell
Tumor-?and circulating-free DNA methylation identifies clinically relevant small cell
lung cancer subtypes
Professor, Thoracic/Head & Neck Medical Oncology
Simon Heeke, Ph.D.
Assistant Professor, Thoracic/Head & Neck Medical Oncology
Professor and Chair, Thoracic/Head & Neck Medical Oncology
Professor, Cancer Biology
David Bruton, Jr. Chair
Elias Jabbour
Professor, Leukemia
D.B. Lane Cancer Research Fund Distinguished Professorship in Leukemia Research
Journal of the American Medical Association
Ponatinib vs Imatinib in Frontline Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia: A Randomized Clinical Trial
Zahraa Rahal, Linghua Wang and Humam Kadara
Nature
An?atlas of epithelial cell states and plasticity in lung adenocarcinoma
Professor, Translational Molecular Pathology and Head & Neck Surgery
Director, Lung Cancer Research Program
Zahraa Rahal, M.D.
Postdoctoral Fellow, Translational Molecular Pathology
Associate Professor, Genomic Medicine
Associate Member, James P. Allison Institute
Co-Lead, Focus Area 2, Institute for Data Science in Oncology
Jordi Rodon
Professor, Investigational Cancer Therapeutics and Genomic Medicine
Clinical Co-Director, Precision Oncology Decision Support Team
Associate Medical Director, Institute for Personalized Cancer Therapy
Nature Medicine
Pemigatinib in previously treated solid tumors with activating FGFR1-FGFR3 alterations: phase 2 FIGHT-207 basket trial
Quarter 4 (June¨CAugust 2024)
Ronald DePinho and Hong Seok Shim
Cell
TERT activation targets DNA methylation and multiple aging hallmarks
Professor
Cancer Biology and Genomic Medicine Research
Harry Graves Burkhart III Distinguished University Chair in Cancer Research
Hong Seok Shim, Ph.D.
Instructor
Boyi Gan and Guang Lei
Boyi Gan, Ph.D.
Professor
Experimental Radiation Oncology and Molecular and Cellular Oncology
N.G. and Helen T. Hawkins Distinguished Professorship for Cancer Research
Guang Lei, M.D., Ph.D.
Instructor
Cancer Discovery
BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers
Raghu Kalluri and Krishnan Kulumani Mahadevan
Science
Type I conventional dendritic cells facilitate immunotherapy in pancreatic cancer
Chair and Professor, Cancer Biology
Frederick F. Becker Distinguished University Chair
Krishnan Mahadevan,?M.B.B.S., Ph.D.
Postdoctoral Fellow
Cancer Biology
Scott Kopetz
Professor, GI Medical Oncology
Del and Dennis McCarthy Distinguished Professorship in Gastrointestinal Cancer Research
Cancer Discovery
Efficacy and Safety of Adagrasib plus Cetuximab in Patients with KRASG12C-Mutated Metastatic Colorectal Cancer
Pawel Mazur
Nature
SMYD5 methylation of rpL40 links ribosomal output to gastric cancer
Assistant Professor
Experimental Radiation Oncology
Funda Meric-Bernstam
Funda Meric-Bernstam, M.D.
Professor and Chair
Investigational Cancer Therapeutics
Journal of Clinical Oncology
Datopotamab Deruxtecan in Advanced or Metastatic HR+/HER2-and Triple-Negative Breast Cancer: Results From the Phase I TROPION-PanTumor01 Study
Jennifer Wargo, Hussein Tawbi and Isabella Glitza
Cancer Discovery
Randomized Placebo-Controlled, Biomarker-Stratified Phase Ib Microbiome Modulation in Melanoma: Impact of Antibiotic Preconditioning on Microbiome and Immunity
Jennifer Wargo, M.D.
Professor
Surgical Oncology and Genomic Med Research
Doctor R Lee Clark Professorship
Hussein Tawbi, M.D., Ph.D.
Professor and Deputy Chair
Melanoma Medical Oncology
Isabella Glitza, M.D., Ph.D.
Professor
Melanoma Medical Oncology