Cheng Laboratory
Xiaodong Cheng, Ph.D.
Principal Investigator
- Departments, Labs and Institutes
- Labs
- Cheng Laboratory
Areas of Research
- Epigenetics
- DNA Methylation
The Cheng Laboratory is defining the structural and biological effects of epigenetic modifications on DNA and histones.
Our Research
Many of our research projects center on the enzymatic readers, writers and erasers of epigenetic modifications on DNA and histones, as well as the rational design of inhibitors that act on these enzymes. We have additional interests in defining how transcription factors recognize DNA modifications.
Selected Notable Publications
Zhou J, Chen Q, Ren R, Yang J, Liu B, Horton JR, Chang C, Li C, Maksoud L, Yang Y, Rotili D, Jain AK, Zhang X, Blumenthal RM, Chen T, Gao Y, Valente S, Mai A, Cheng X. Cell Chem Biol. 2024 Oct 14:S2451-9456(24)00403-3.
Hardikar S, Ren R, Ying Z, Horton JR, Bramble MD, Liu B, Lu Y, Liu B, Dan J, Zhang X, Cheng X, Chen T. Sci Adv. 2024 Aug 23;10(34):eadr0036.
Yang J, Horton JR, Liu B, Corces VG, Blumenthal RM, Zhang X, Cheng X. Nucleic Acids Res. 2023 Sep 8;51(16):8447-8462.
Chen Q, Liu B, Zeng Y, Hwang JW, Dai N, Corr¨ºa IR Jr, Estecio MR, Zhang X, Santos MA, Chen T, Cheng X. NAR Cancer. 2023 May 17;5(2):zcad022.
Pappalardi MB, Keenan K, Cockerill M, Kellner WA, Stowell A, et al. . Nat Cancer . 2021 Oct;2(10):1002-1017.
Zhou J, Horton JR, Blumenthal RM, Zhang X, Cheng X. . Nat Commun. 2021 Jun 8;12(1):3436.
Zeng Y, Ren R, Kaur G, Hardikar S, Ying Z, Babcock L, Gupta E, Zhang X, Chen T, Cheng X. . Genes Dev. 2020 Nov 1;34(21-22):1546-1558.
Horton JR, Woodcock CB, Opot SB, Reich NO, Zhang X, Cheng X. . Nat Commun. 2019 Oct 10;10(1):4600.
Dai S, Horton JR, Woodcock CB, Wilkinson AW, Zhang X, Gozani O, Cheng X. . Nat Commun. 2019 Aug 6;10(1):3541.
Patel A, Yang P, Tinkham M, Pradhan M, Sun MA, Wang Y, Hoang D, Wolf G, Horton JR, Zhang X, Macfarlan T, Cheng X. Cell. 2018 Mar 22;173(1):221-233.e12.
Hashimoto H, Wang D, Horton JR, Zhang X, Corces VG, Cheng X. . Mol Cell. 2017 Jun 1;66(5):711-720.e3.