Â鶹ӳ»­

260. Kaur G, Horton JR, Tzertzinis G, Zhou J, Schildkraut I, Cheng X. (2025) Structural basis of substrate specificity of Helix pomatia AMP deaminase and a chimeric ADGF adenosine deaminase. [BioRxiv posted 2025 March 27]

259. Horton JR, Yu M, Zhou J, Tran M, Anakal RR, Lu Y, Blumenthal RM, Zhang X, Huang Y, Zhang X, Cheng X. (2025) . Nat Commun. 16(1): 3672. doi: 10.1038/s41467-025-58998-7. [Epub 2025 Apr 17]

258. Song S, Fan Y, Zou G, Huo L, Kumar J, Li Y, Wang R, Dai E, Jin J, Scott AW, Shao S, Pizzi MP, Vykoukal JV, Katayama H, Hanash S, Calin GA, Zhang X, Lee MG, Wang Z, Lo YH, Gan Q, Waters RE, Yin F, Wang L, Cheng X, Ajani JA, Dhar SS. (2025) . Cancer Lett. 621: 217695 doi: 10.1016/j.canlet.2025.217695. [Epub 2025 Apr 4]

257. Xu S, Peng C, Ren R, Lu H, Zhao H, Xia S, Shen Y, Xu B, Zhang H, Cheng X, Blobel GA, Lan X. (2025) . Cell Rep. 44(4):115476. doi: 10.1016/j.celrep.2025.115476. [Epub 2025 Mar 28]

256. Qian C, Lee Y, Han Y, Zhong Y, Zhou J, Hrit J, Xie L, Chen Q, Kaniskan H?, Chen X, Rothbart S, Cheng X, Xiong Y, Jin J. (2025) . J Med Chem. 68(3): 2903-2919. doi: 10.1021/acs.jmedchem.4c02161. [Epub 2025 Feb 5]

255. Zhou J, Chen Q, Ren R, Yang J, Liu B, Horton JR, Chang C, Li C, Maksoud L, Yang Y, Rotili D, Zhang X, Blumenthal RM, Chen T, Gao Y, Valente S, Mai A, Cheng X. (2024) . Cell Chem Biol. 31(12): 2112-2127.e6. doi: 10.1016/j.chembiol.2024.09.007 [Epub 2024 Oct 21] BioRxiv preprint doi: [posted on 2024 April 3] [see MD Anderson Research Highlights for October 30, 2024]

254. Zhang X, Blumenthal RM, Cheng X. (2024) . Nucleic Acids Res. 52(19): 11442¨C11454. doi: 10.1093/nar/gkae832. [Epub 2024 Sep 26]

253. Hardikar S, Ren R, Ying Z, Zhou J, Horton JR, Bramble MD, Liu B, Lu Y, Liu B, Coletta LD, Shen J, Dan J, Zhang X, Cheng X, Chen T. (2024) . Sci Adv. 10(34): eadr0036. doi: 10.1126/sciadv.adr0036. [Epub 2024 Aug 23] [BioRxiv preprint doi: 10.1101/2023.12.15.571946 on 2023 Dec 15][see MD Anderson Research Highlights for September 4, 2024]

252. Wang Y, Zhou J, He W, Fu R, Shi L, Dang NK, Liu B, Xu H, Cheng X, Bedford MT. (2024) . Cell Rep. 43(7):114459. doi: 10.1016/j.celrep.2024.114459. [Epub 2024 Jul 9]

251. Zhang X, Blumenthal RM, Cheng X. (2024) Keep fingers on the CpG islands. Epigenomes 8(2): 23. https://doi.org/10.3390/epigenomes8020023 [Epub 2024 Jun 19]

250. Zhang X, Blumenthal RM, Cheng X. (2024) . Curr Opin Struct Biol. 87: 102836. doi: 10.1016/j.sbi.2024.102836. [Epub 2024 May 15]

249. Zhou J, Chen T, Cheng X. (2024) . Structure 32(3): 258-260. doi: 10.1016/j.str.2024.01.009 [2024 Mar 7]

248. Xu S, Ren R, Peng C, Lu H, Ly LC, Crossley M, Xu B, Cheng X, Blobel GA, Lan X. (2024) Mechanistic dissection of the CHD4 enhancers reveals cooperative functions among the homotypic ZNF410 clustered motifs. BioRxiv preprint: [2024 Feb 25].

206. Horton JR, Yang J, Zhang X, Petronzio T, Fomenkov A, Wilson GG, Roberts RJ, Cheng X (2020) . Nucleic Acids Res. 48(3): 1466-1478 doi: 10.1093/nar/gkz1195. [Epub Dec 27, 2019] - published as cover on February 20, 2020

205. Woodcock CB, Yu D, Hajian T, Li J, Huang Y, Dai N, Correa IR Jr, Wu T, Vedadi M, Zhang X, Cheng X (2019) . Cell Discov. 5: 63. doi: 10.1038/s41421-019-0136-4 [Epub Dec 24]

204. Wu X, Liu S, Sagum C, Chen J, Singh R, Chaturvedi A, Horton JR, Kashyap TR, Fushman D, Cheng X, Bedford MT, Wang B (2019) . Genes Dev. 33(23-24): 1702-1717. [Epub Nov 7] - see Outlook by Rona G and Pagano M (2019) . Genes Dev. 33(23-24): 1615-1616

203. Yang J, Zhang X, Blumenthal RM, Cheng X (2020) . J Mol Biol. 432: 1661-1673. [Epub Oct 15, 2019]

202. Horton JR, Woodcock CB, Opot SB, Reich NO, Zhang X, Cheng X (2019) . Nat Commun. 10(1): 4600. doi: 10.1038/s41467-019-12498-7. [Epub Oct 10]

201. Zoeller EL, Pedro B, Konen J, Dwivedi B, Rupji M, Sundararaman N, Wang L, Horton JR, Zhong C, Barwick BG, Cheng X, Martinez ED, Torres MP, Kowalski J, Marcus AI, Vertino PM (2019) . J Cell Sci. 132(19). pii: jcs.231514. doi: 10.1242/jcs.231514. [Epub Sept 12] See cover image

200. Woodcock CB, Yu D, Zhang X, Cheng X (2019) . Cell Discovery 5: 50. doi: 10.1038/s41421-019-0119-5 [Epub Sept 10]

199. Dai S, Horton JR, Woodcock CB, Wilkinson AW, Zhang X, Gozani O, Cheng X (2019) . Nat Commun. 10(1): 3541. doi: 10.1038/s41467-019-11554-6 [Epub Aug 6]

198. Ren R, Hardikar S, Horton JR, Lu Y, Zeng Y, Singh AK, Lin K, Coletta LD, Shen J, Lin Kong CS, Hashimoto H, Zhang X, Chen T, Cheng X (2019). . Nucleic Acids Res. 47(16): 8388-8398. doi: 10.1093/nar/gkz557. [Epub June 21]

197. Yang J, Horton JR, Li J, Huang Y, Zhang X, Blumenthal RM, Cheng X (2019) . Nucleic Acids Res. 47(16): 8375-8387. doi: 10.1093/nar/gkz381 [Epub May 13]

196. Milite C, Feoli A, Horton JR, Rescigno D, Cipriano A, Pisapia V, Viviano M, Pepe G, Amendola G, Novellino E, Cosconati S, Cheng X, Castellano S, Sbardella G. (2019) . J Med Chem. 62(5): 2666-2689 [Epub Feb 12]

195. Yang J, Horton JR, Wang D, Ren R, Li J, Sun D, Huang Y, Zhang X, Blumenthal RM, Cheng X (2019) . Nucleic Acids Res. 47(4): 1774-1785 [Epub Dec 19, 2018]

194. Wilkinson AE, Diep J, Dai S, Liu S, Ooi YS, Song D, Li TM, Horton JR, Zhang X, Liu C, Trivedi DV, Ruppel KM, Vilches-Moure JG, Casey KM, Mak J, Cowan T, Elias JE, Nagamine CM, Spudich JA, Cheng X*, Carette JE*, Gozani O* (2019) . *Co-corresponding authors. Nature 565(7739): 372-376 [Epub Dec 10, 2018] see comment by P. Lappalainen: . Nature 565(7739): 297-298 (2019) and has been recommended in F1000Prime as being of special significance in its field by F1000 Faculty Member Pekka Lappalainen.

193. Horton JR, Woodcock CB, Chen Q, Liu X, Zhang X, Shanks J, Rai G, Mott BT, Jansen DJ, Kales SC, Henderson MJ, Cyr M, Pohida K, Hu X, Shah P, Xu X, Jadhav A, Maloney DJ, Hall MD, Simeonov A, Fu H, Vertino PM, Cheng X (2018) . J Med Chem. 61(23): 10588¨C10601 [Epub Nov 3]

192. Wu L, Cao J, Cai WL, Lang SM, Horton JR, Jansen DJ, Liu ZZ, Chen JF, Zhang M, Mott BT, Pohida K, Rai G, Kales SC, Henderson MJ, Hu X, Jadhav A, Maloney DJ, Simeonov A, Zhu S, Iwasaki A, Hall MD, Cheng X, Shadel GS, Yan Q (2018) . PLoS Biol. 16(8): e2006134. eCollection 2018 Aug.

191. Ren R, Horton JR, Zhang X, Blumenthal RM, Cheng X (2018) . Curr Opin Struct Biol. 53: 88-99

190. Patel A, Yang P, Tinkham M, Pradhan M, Sun MA, Wang Y, Hoang D, Wolf G, Horton JR, Zhang X, Macfarlan T, Cheng X (2018) . Cell 173(1): 221-233 [Epub Mar 15]

189. Horton JR, Liu X, Wu L, Zhang K, Shanks J, Zhang X, Rai G, Mott BT, Jansen DJ, Kales SC, Henderson MJ, Pohida K, Fang Y, Hu X, Jadhav A, Maloney DJ, Hall MD, Simeonov A, Fu H, Vertino PM, Yan Q, Cheng X (2018) . J Med Chem. 61(7): 3193-3208 [Epub Mar 14]

188. Wang D, Horton JR, Zheng Y, Blumenthal RM, Zhang X, Cheng X (2018) . Nucleic Acids Res. 46(8): 3864-3877 [Epub 2017 Dec 27]

187. Murray IA, Morgan RD, Luyten Y, Fomenkov A, Corr¨ºa IR Jr, Dai N, Allaw MB, Zhang X, Cheng X, Roberts RJ (2018) . Nucleic Acids Res. 46(2): 840-848 [Epub 2017 Dec 8]

186. Youngblood B, Hale, JS, Kissick HT, Ahn E, Xu X, Wieland A, Araki K, West EE, Ghoneim HE, Fan Y, Dogra P, Davis CW, Konieczny BT, Anata R, Cheng X, Ahmed R (2017) . Nature 552(7685): 404-409 [Epub Dec 13]

185. Lee CC, Peng SH, Shen L, Lee CF, Du TH, Kang ML, Xu GL, Upadhyay AK, Cheng X, Yan YT, Zhang Y, Juan LJ. (2017) . Mol Cell 68(1): 89-103 [Epub Sep 21]

184. Horton JR, Gale M, Yan Q, Cheng X (2017) The Molecular Basis of Histone Demethylation. In DNA and Histone Methylation as Cancer Targets (A. Kaneda, Y.-i. Tsukada, eds., Cancer Drug Discovery and Development, DOI 10.1007/978-3-319-59786-7_7), pp 151-219

183. Patel A, Zhang X, Blumenthal RM, Cheng X (2017) . J Biol Chem. 292(39): 15994-16002 [Epub Aug 11]

182. Yang P, Wang Y, Hoang D, Tinkham M, Patel A, Sun MA, Wolf G, Baker M, Chien HC, Lai KN, Cheng X, Shen CJ, Macfarlan TS (2017) . Science 356(6339): 757-759 [Epub May19]

181. Hashimoto H, Wang D, Horton JR, Zhang X, Corces VG, Cheng X (2017) . Mol Cell 66(5): 711-720 [Epub May 18]

180. Head PE, Zhang H, Bastien AJ, Koyen AE, Withers AE, Daddacha WB, Cheng X, Yu DS (2017) . J. Biol. Chem. 292(24): 9919-9931 [Epub May 1]

179. Hong S, Wang D, Horton JR, Zhang X, Speck SH, Blumenthal RM, Cheng X (2017) . Nucleic Acids Res. 45(5): 2503-2515 [Epub Feb 1, 2017] This paper was published as the cover story in the March 17, 2017 issue of Nucleic Acids Research

178. Wang D, Hashimoto H, Zhang X, Barwick BG, Lonial S, Boise LH, Vertino PM, Cheng X (2017) . Nucleic Acids Res. 45(5): 2396-2407 [Epub Nov 28, 2016]

177. Hong S, Cheng X (2016) . Adv. Exp. Med. Biol. 945: 321-341

176. Hashimoto H, Wang D, Steves AN, Jin P, Blumenthal RM, Zhang X, Cheng X (2016) . Nucleic Acids Res. 44(21): 10177-10185 [Epub Sep 4]

175. Hashimoto H, Zhang X, Zheng Y, Wilson GG, Cheng X (2016) . Nucleic Acids Res. 44(21): 10165-10176 [Epub Sep 4]

174. Horton JR, Liu X, Gale M, Wu L, Shanks JR, Zhang X, Webber PJ, Bell JS, Kales SC, Mott BT, Rai G, Jansen DJ, Henderson MJ, Urban DJ, Hall MD, Simeonov A, Maloney DJ, Johns MA, Fu H, Jadhav A, Vertino PM, Yan Q, Cheng X (2016) . Cell Chem. Biol. 23(7): 769-81 [Epub Jul 14]

173. Patel A, Hashimoto H, Zhang X, Cheng X (2016) . Methods in Enzymology 573: 387-401 [Epub Feb 16]

172. Patel A, Horton JR, Wilson GG, Zhang X, Cheng X (2016) . Genes Dev. 30(3): 257-65. [Epub Feb 1] This paper was published as the cover story in the February 1, 2016 issue of Genes & Development.

171. Zeng Y, Yao B, Shin J, Lin L, Kim N, Song Q, Liu S, Su Y, Guo JU, Huang L, Wan J, Wu H, Qian J, Cheng X, Zhu H, Ming GL, Jin P, Song H. (2016) . Mol Cell. 61(1): 153-60 [Epub 2015 Dec 16]

170. Horton JR, Engstrom A, Zoeller EL, Liu X, Shanks JR, Zhang X, Johns MA, Vertino PM, Fu H, Cheng X. (2015) . J. Biol. Chem. 291(6): 2631-46 [Epub 2015 Dec 8]

169. Est¨¨ve PO, Zhang G, Ponnaluri VK, Deepti K, Chin HG, Dai N, Sagum C, Black K, Corr¨ºa IR Jr, Bedford MT, Cheng X, Pradhan S. (2015) . Nucleic Acids Res. 44(4): 1642-56 [Epub 2015 Nov 8]

168. Hashimoto H, Pais JE, Dai N, Corr¨ºa IR Jr, Zhang X, Zheng Y, Cheng X. (2015) . Nucleic Acids Res. 43(22): 10713-21[Epub Aug 31]          

167. Hashimoto H, Zhang X, Vertino PM, Cheng X (2015) s. J Biol Chem. 290: 20712-22 [Epub July 7]

166. Collins RE and Cheng X (2015) Methyl-Lysine Recognition by Ankyrin-Repeat Proteins. pp 101-124. In Histone Recognition, M.-M. Zhou (ed.), Springer International Publishing Switzerland. DOI 10.1007/978-3-319-18102-8_5

165. Cheng X and Trievel RC (2015) JmjC Lysine Demethylases. pp 210-245. In 2-Oxoglutarate-Dependent Oxygenases, RSC Metallobiology Series No. 3, Edited by Robert P Hausinger and Christopher J Schofield. The Royal Society of Chemistry. DOI:10.1039/9781782621959-00210

164. Horton JR, Zhang X, Blumenthal RM, Cheng X (2015) . Nucleic Acids Res. 43(8): 4296-308 [Epub Apr 6]

163. Pais JE, Dai N, Tamanaha E, Vaisvila R, Fomenkov AI, Bitinaite J, Sun Z, Guan S, Corr¨ºa IR Jr, Noren CJ, Cheng X, Roberts RJ, Zheng Y, Saleh L. (2015) . Proc Natl Acad Sci U S A. 112(14): 4316-21 [Epub Mar 23]

162. Myrick LK, Deng P, Hashimoto H, Oh YM, Cho Y, Poidevin MJ, Suhl JA, Visootsak J, Cavalli V, Jin P, Cheng X, Warren ST, Klyachko VA (2015) . Proc Natl Acad Sci U S A. 112(4): 949-956 [Epub Jan 5]

161. Daugherty AB, Horton JR, Cheng X, Lutz S. (2015) . ACS Catal. 5: 892-899 [Epub 2014 Dec 9]

160. Myrick LK, Hashimoto H, Cheng X, Warren ST (2015) . Hum Mol Genet. 24(6): 1733-40 [Epub 2014 Nov 20]

159. Horton JR, Wang H, Mabuchi MY, Zhang X, Roberts RJ, Zheng Y, Wilson GG, Cheng X (2014) . Nucleic Acids Res. 42(19): 12092-101 [Epub Sept 27]

158. Hashimoto H, Olanrewaju YO, Zheng Y, Wilson GG, Zhang X, Cheng X (2014) . Genes Dev. 28(20): 2304-13 [Epub Sept 25]

157. Hong S, Hashimoto H, Kow YW, Zhang X, Cheng X (2014) . J. Mol. Biol. 426: 3703-12 [Epub Sept. 21]

156. Cheng X, Roberts RJ (2014) Base Flipping. In: eLS. John Wiley & Sons, Ltd: Chichester. DOI: 10.1002/9780470015902.a0002714.pub [Epub Aug 15]

155. Cheng X (2014) . Cold Spring Harb Perspect Biol. 6(8). pii: a018747. doi:10.1101/cshperspect.a018747 [Epub Aug 1]

154. Kao TH, Liao HF, Wolf D, Tai KY, Chuang CY, Lee HS, Kuo HC, Hata K, Zhang X, Cheng X, Goff SP, Ooi SK, Bestor TH, Lin SP (2014) . J Virol. 88(18): 10680-95 [Epub Jul 2]

153. Horton JR, Borgaro JG, Griggs RM, Quimby A, Guan S, Zhang X, Wilson GG, Zheng Y, Zhu Z, Cheng X (2014) . Nucleic Acids Res. 42(12): 7947-59 [Epub June 3]

152. Rotili D, Tarantino D, Marrocco B, Gros C, Masson V, Poughon V, Ausseil F, Chang Y, Labella D, Cosconati S, Di Maro S, Novellino E, Schnekenburger M, Grandjenette C, Bouvy C, Diederich M, Cheng X, Arimondo PB, Mai A. (2014) . PLoS One 9(5): e96941 [Epub May 8]

151. Horton JR, Nugent RL, Li A, Mabuchi MY, Fomenkov A, Cohen-Karni D, Griggs RM, Zhang X, Wilson GG, Zheng Y, Xu SY, Cheng X (2014) . Sci Rep. 4: 4246 [Epub Mar 7]

150. Liu Y, Olanrewaju YO, Zheng Y, Hashimoto H, Blumenthal RM, Zhang X, Cheng X (2014) Nucleic Acids Res. 42(8): 4859-67 [Epub Feb 11]

149. Myrick LK, Nakamoto-Kinoshita M, Lindor NM, Kirmani S, Cheng X, Warren ST (2014) . Eur J Hum Genet. doi: 10.1038/ejhg.2013.311. [Epub 2014 Jan 22]

148. Valente S, Liu Y, Schnekenburger M, Zwergel C, Cosconati S, Gros C, Tardugno M, Labella D, Florean C, Minden S, Hashimoto H, Chang Y, Zhang X, Kirsch G, Novellino E, Arimondo PB, Miele E, Ferretti E, Gulino A, Diederich M, Cheng X, Mai A (2014) . J. Med. Chem. 57: 701-13 [Epub 2014 Jan 4]

147. Hashimoto H, Pais JE, Zhang X, Saleh L, Fu ZQ, Dai N, Corr¨ºa IR, Zheng Y, Cheng X (2014) . Nature 506: 391-5 [Epub 2013 Dec. 25]

146. Liu Y, Olanrewaju YO, Zhang X, Cheng X (2013) . Biochemistry 52: 9301-7 [Epub Nov 15]

145. Hashimoto H, Zhang X, Cheng X (2013) . DNA Repair 12, 535-540 [Epub May 13]

144. Nicholson TB, Singh AK, Su H, Hevi S, Wang J, Bajko J, Li M, Valdez R, Goetschkes M, Capodieci P, Loureiro J, Cheng X, Li E, Kinzel B, Labow M, Chen T (2013) . PLoS One. 8(4): e60913 [April 24]

143. Cheng X, Hashimoto H (2013) . Encyclopedia of Biological Chemistry 3: 6-10 [ (2021) 3, pp. 330¨C335]

142. Sun Z, Terragni J, Borgaro JG, Liu Y, Yu L, Guan S, Wang H, Sun D, Cheng X, Zhu Z, Pradhan S, Zheng Y (2013) . Cell Reports 3: 567-576 [Epub Jan 24]

141. Liu Y, Zhang X, Blumenthal RM, Cheng X (2013) . Trends Biochem Sci. 38: 177-183 [Epub Jan 22]

140. Cheng X and Blumenthal RM (2013) TiBS 38(9), 423

139. Hashimoto H, Zhang X, Cheng X (2013) . J. Mol. Biol. 425(6): 971-6 [Epub Jan 19]

138. Liu Y, Toh H, Sasaki H, Zhang X, Cheng X (2012) . Genes Dev. 26, 2374-9 [Epub Oct 11]

137. Hashimoto H, Hong S, Bhagwat AS, Zhang X, Cheng X. (2012) . Nucleic Acids Res. 40, 10203-14 [Epub Sept 8]

136. Horton JR, Mabuchi MY, Cohen-Kamo D, Zhang, X, Griggs RM, Samaranayake M, Roberts RJ, Zheng Y, Cheng X (2012) . Nucleic Acids Res. 40, 9763-73 [Epub July 30]
This paper was published as the cover story in vol. 40(19) issue of NAR.

135. Hashimoto H, Zhang X, Cheng X (2012) . Nucleic Acids Res. 40, 8276-84 [Epub June 27]

134. Hashimoto H, Liu Y, Upadhyay AK, Chang Y, Howerton SB, Vertino PM, Zhang X, Cheng X (2012) . Nucleic Acids Res. 40, 4841-9 [Epub Feb 22]

133. Upadhyay AK, Rotili D, Han JW, Hu R, Chang Y, Labella D, Zhang X, Yoon YS, Mai A, Cheng X (2012) . J. Mol. Biol. 416, 319-327 [Epub Dec 29 2011]
This paper was published as the cover story in the February 24, 2012 issue of JMB.

132. Chang Y, Sun L, Kokura K, Horton JR, Fukuda M, Espejo A, Izumi V, Koomen JM, Bedford MT, Zhang X, Shinkai Y, Fang J, Cheng X (2011) Nat Commun. 2: 533. doi: 10.1038/ncomms1549. [Epub Nov 15]

131. Szulwach KE, Li X, Li Y, Song CX, Wu H, Dai Q, Irier H, Upadhyay AK, Gearing M, Levey AI, Vasanthakumar A, Godley LA, Chang Q, Cheng X, He C, Jin P (2011) . Nat Neurosci. 14, 1607-16 [Epub Oct 30]

130. Zhao J, Du Y, Horton JR, Upadhyay AK, Lou B, Bai Y, Zhang X, Du L, Li M, Wang B, Zhang L, Barbieri JT, Khuri FR, Cheng X, Fu H (2011) . Proc Natl Acad Sci U S A. 108, 16212-6 [Epub Sept 9]

129. Upadhyaya AK, Horton JR, Du Y, Bai, Y, Cheng X, and Fu H (2013) Reply to R?glin et al.: Synchrotron radiation-induced covalent modification of 14-3-3¦Æ by diazene compounds containing pyridoxal phosphate. PNAS, 109 (18), E1054

128. Upadhyay AK, Horton JR, Zhang X, Cheng X (2011) . Curr. Opin. Struct. Biol. 21, 750-760 [Epub Aug 25]

127. Cheng X, Blumenthal RM (2011) . Prog. Mol. Biol. Transl. Sci. 101, 1-21. (Preface for the volume - Modification of Nuclear DNA and its Regulatory Proteins, Cheng and Blumenthal, editors; ISBN 978-0-12-387685-0)

126. Chang Y, Levy D, Horton JR, Peng J, Zhang X, Gozani O, Cheng X (2011) . Nucleic Acids Res. 39, 6380-9 [Epub April 22]
This paper was published as the cover story in the August 15, 2011 issue of NAR.

125. Chang Y, Horton JR, Bedford MT, Zhang X, Cheng X (2011) . J. Mol. Biol. 408, 807-14 [Epub March 23]

124. Horton JR, Upadhyay AK, Hashimoto H, Zhang X, Cheng X (2011) . J. Mol. Biol. 406, 1-8 [Epub 2010 Dec 15]

123. Est¨¨ve PO, Chang Y, Samaranayake M, Upadhyay AK, Horton JR, Feehery GR, Cheng X, Pradhan S (2011) . Nat Struct Mol Biol. 18, 42-48 [Epub 2010 Dec 12]

122. Levy D, Kuo, AJ, Chang Y, Schaefer U, Kitson C, Cheung P, Espejo A, Zee BM, Liu CL, Tangsombatvisit S, Tennen RI, Kuo AY, Tanjing S, Cheung R, Chua KF, Utz PJ, Shi X, Prinjha RK, Lee K, Garcia BA, Bedford MT, Tarakhovsky A, Cheng X, Gozani O (2011) . Nat Immunol. 12, 29-36 [Epub 2010 Dec 5]

121. Upadhyay AK, Cheng X (2011) . In Progress in Drug Research: Epigenetics and Disease (S. Gasser and E. Li, editors) 67, 107-124

120. Hashimoto H, Vertino PM, Cheng X (2010) . Epigenomics 2(5), 657-669

119. Cheng X, Hashimoto H, Horton JR, Zhang X (2010) Mechanisms of DNA methylation, methyl-CpG recognition, and demethylation in mammals. In: Handbook of Epigenetics: The New Molecular and Medical Genetics (Trygve Tollefsbol, editor). Oxford: Academic Press (ISBN: 978-0-12-375709-8) (DOI: 10.1016/B978-0-12-375709-8.00002-2) pp 9-24

118. Lee CF, Ou DS, Lee SB, Chang LH, Lin RK, Li YS, Upadhyay AK, Cheng X, Wang YC, Hsu HS, Hsiao M, Wu CW, Juan LJ (2010) . J Clin Invest. 120, 2920-30 [Epub July 1]

117. Chang Y, Ganesh T, Horton JR, Spannhoff A, Liu J, Sun A, Zhang X, Bedford MT, Shinkai Y, Snyder JP, Cheng X (2010) . J Mol Biol. 400, 1-7 [Epub Apr 28]
This paper was published as the cover story in the July 2, 2010 issue of JMB.

116. Cheng X and Blumenthal RM (2010) . Biochemistry 49, 2999-3008 [Epub March 8]
This paper was the ten most-accessed articles during the second quarter of 2010.

115. Cheng X and Roberts RJ (2010) Base Flipping. In: ENCYCLOPEDIA OF LIFE SCIENCES 2010, John Wiley & Sons, Ltd: Chichester [DOI: 10.1002/9780470015902.a0002714.pub2]

114. Collins R and Cheng X. (2010) . Nucleic Acids Res. 38, 3503-11 [Epub Feb 16]

113. Horton JR, Upadhyay AK, Qi HH, Zhang X, Shi Y, Cheng X (2010) . Nat Struct Mol Biol. 17, 38-43 [Epub 2009 Dec 20]

112. Z Qian, JR Horton, X Cheng, S Lutz (2009) . J. Mol. Biol. 393, 191-201 [Epub Aug 13]

111. D. Jia, X. Cheng (2009) Methylation on the nucleosome: from DNA to Histone. Nutrients and Epigenetics (CRC Press, editors: Sang Woon Choi and Simonetta Friso) pp 7-35

110. X. Cheng, R.M. Blumenthal (2009) Structural and Biochemical Advances in Mammalian DNA Methylation. Epigenomics (Springer publishers, Editors: Rob Martienssen, John Greally and Anne Ferguson-Smith) pp 85-100

109. T. Gao, R.E. Collins, J.R. Horton, X. Zhang, R. Zhang, A. Dhayalan, R. Tamas, A. Jeltsch, X. Cheng (2009) . Proteins 76, 772-7 [Epub April 8]

108. Chang Y, Zhang X, Horton JR, Upadhyay AK, Spannhoff A, Liu J, Snyder JP, Bedford MT, Cheng X (2009) . Nat Struct Mol Biol. 16, 312-7 [Epub Feb 15]

107. Hashimoto H, Horton JR, Zhang X, Cheng X. (2009) . Epigenetics 4, 8-14

106. Cheng X, Blumenthal RM (2008) Structures and activities of mammalian DNA methyltransferases. In DNA and RNA Modification Enzymes: Comparative Structure, Mechanism, Functions, Cellular Interactions and Evolution (Edited by: Henri Grosjean) ISBN: 978-1-58706-329-9

105. R.Z. Jurkowska, N. Ansbach, C. Urbanke, D. Jia, R. Reinhardt, W. Nellen, X. Cheng, A. Jeltsch (2008) . Nucleic Acids Res. 36, 6656-63 [Epub Oct 22]

104. H. Hashimoto, J.R. Horton, X. Zhang, M. Bostick, S. Jacobsen, X. Cheng (2008) . Nature 455, 826-829 [Epub Sept 3]

103. P. Rathert, A. Dhayalan, M. Murakami, X. Zhang, R. Tamas, R. Jurkowska, Y. Komatsu, Y. Shinkai, X. Cheng, A. Jeltsch (2008) . Nature Chem. Biol. 4, 344-346

102. K. Subramanian, D. Jia, P. Kapoor-Vazirani, D. R. Powell, R. E. Collins, D. Sharma, J. Peng, X. Cheng, P. M. Vertino (2008) . Mol. Cell 30, 336-47

101. X. Cheng, R.M. Blumenthal (2008) . Structure 16, 341-50

100. R. E. Collins, J. P. Northrop, J. R. Horton, D. Y. Lee, X. Zhang, M. R. Stallcup, X. Cheng (2008) . Nature Struct. Mol. Biol. 15, 245-50 [Epub Feb 10] See News and Views by Brent and Marmorstein (2008) . Nat Struct Mol Biol. 15, 221-2

99. P. Rathert, X. Zhang, C. Freund, X. Cheng, A. Jeltsch (2008) . Chemistry & Biology 15, 5-11

98. A. Dhayalan, T. P. Jurkowski, H. Laser, R. Reinhardt, D. Jia, X. Cheng, A. Jeltsch (2008) . J. Mol. Biol. 376, 1091-99 [Epub Dec 23 2007]

97. P. Rathert, X. Cheng, A. Jeltsch (2007) . BioTechniques 43, 602-608

96. T.C. Osborne, O. Obianyo, X. Zhang, X. Cheng, P.R. Thompson (2007) . Biochemistry 46, 13370-81 [Epub Oct 26]

95. D. Jia, R. Jurkowska, X. Zhang, A. Jeltsch, X. Cheng (2007) . Nature 449, 248-251 [Epub Aug 22]

94. F. Lan, R. E Collins, R. del Cegli, R. Alpatov, J. R. Horton, X. Shi, O. Gozani, X. Cheng, and Y. Shi (2007) . Nature 448 718-722   

93. SK. Ooi, C. Qiu, E. Bernstein, K. Li, D. Jia, Z. Yang, H. Erdjument-Bromage, P. Tempst, SP. Lin, C. D. Allis, X. Cheng, and T. H. Bestor (2007) . Nature 448, 714-717

92. K. Higashimoto, P. Kuhn, D. Desai, X. Cheng, W. Xu (2007) . PNAS 104, 12318-12323 [Epub July 17]

91. K. Liebert, J. R. Horton, S. Chahar, M. Orwick, X. Cheng, A. Jeltsch (2007) . J. Biol. Chem. 282, 22848-22855 [Epub May 31]

90. D.Y. Lee, I. Ianculescu, D. Purcell, X. Zhang, X. Cheng and M.R. Stallcup (2007) . Molecular Endocrinology 21, 1381-1393 [Epub Apr 10]

89. J.R. Horton, S.J. Elgar, S.I. Khan, X. Zhang, P.A. Wade, X. Cheng (2007) . Proteins 67, 1198-1202 [Epub March 21]

88. X. Cheng, X. Zhang (2007) . Mutation Res. 618, 102-115 [Epub Jan 21]

87. H. Wu, J. R. Horton, K. Battaile, A. Allali-Hassani, F. Martin, H. Zeng, P. Loppnau, M. Vedadi, A. Bochkarev, A. N. Plotnikov, X. Cheng (2007) Proteins 67, 198-208 [Epub Jan 22]

86. R.E. Collins, X. Cheng (2006) . J. Cell. Biochem. 99, 1251-1266 [Epub Aug 22]
This review was published as the cover story in the December 1, 2006 issue of JCB.

85. J. Mercante, K. Suzuki, X. Cheng, P. Babitzke, T. Romeo (2006) . J. Biol. Chem. 281, 31832-42 [Epub Aug 21]

84. X. Zhang, X. Cheng (2006) . The Enzymes Vol. 24, pp 101-117

83. H.L. Schubert, R.M. Blumenthal, X. Cheng (2006) . The Enzymes Vol. 24, pp 1-26

82. F. E. Reyes, J. R. Horton, J. E. Mullally, A. Heroux, X. Cheng, K. D. Wilkinson (2006) . Cell 124, 1197-1208
(see minireview by J. Wade Harper and Brenda A. Schulman (2006) . Cell 124, 11133-1136

81. J. R. Horton, K. Liebert, M. Bekes, A. Jeltsch, X. Cheng (2006) . J. Mol. Biol. 358, 559-570

80. J. R. Horton, X. Zhang, R. Maunus, Z. Yang, G. G. Wilson, R. J. Roberts and X. Cheng (2006) . Nucleic Acids Res. 34, 938-948

79. J.R. Horton, K. Sawada, M. Nishibori, and X. Cheng (2005) . J. Mol. Biol. 353, 334-344
This paper is published as the cover story in the October 21, 2005 issue of JMB.

78. R. E. Collins, X. Cheng (2005) . FEBS Letters 579, 5841-5849 [Epub Aug 15]
One of the top 25 most downloaded articles of FEBS Letters in 2005 (Certified by Anthony Newman, Publishing editor for the journal)

77. S.C. Dillon, X. Zhang, R.C. Trievel, X. Cheng (2005) . Genome Biology 6(8): 227 [Epub Aug 2]

76. H. Gowher, X. Zhang, X. Cheng, A. Jeltsch (2005) . Analytic Biochemistry 342, 287-291 (Epub May 31)                               

75. J.R. Horton, K. Liebert, S. Hattman, A. Jeltsch, X. Cheng (2005) . Cell, 121, 349-361 (featured in the 2005 annual report of the Advanced Photon Source at Argonne National Laboratory, p105)

74. Z. Yang, J.R. Horton, R. Maunus, G.G. Wilson, R.J. Roberts and X. Cheng (2005) . Nucleic Acids Res. 33, 1892-1901

73. X. Cheng, R.E. Collins, X. Zhang (2005) . Ann. Rev. Biophys. Biomol. Struct. 34, 267-294

72. R.E. Collins, M. Tachibana, H. Tamaru, K.M. Smith, D. Jia, X. Zhang, E.U. Selker, Y. Shinkai, X. Cheng (2005) . J. Biol. Chem. 280, 5563-5570 (epub on Dec. 6, 2004)

71. J.C. Amor, J. Swails, C. R. Roy, H. Nagai, A. Ingmundson, X. Cheng, R. A. Kahn (2005) The structure of RalF, an Arf guanine nucleotide exchange factor from Legionella penumophila, reveals the presence of a cap over the active site. J. Biol. Chem. 280, 1392-1400 (Epub on Nov. 1, 2004)

70. K. Sawada, Z. Yang, J.R. Horton, R.E. Collins, X. Zhang, and X. Cheng (2004) Structure of the conserved core of the Yeast Dot1p, a nucleosomal histone H3 lysine79 methyltransferase. J. Biol. Chem. 279, 43296-43306 (Epub on July 29, 2004).
This paper was published as the cover story in the October 8, 2004 issue of JBC.

69. J.R. Horton, G. Ratner, N.K. Banavali, N.Huang, Y. Choi, M.A. Maier, A.D. MacKerell , V.E. Marquez, X. Cheng (2004) Caught in the act: visualization of an Intermediate in the DNA base flipping pathway induced by HhaI methyltransferase. Nucleic Acids Res. 32, 3877-3886
This paper was published as the cover story in Vol. 32, No. 13 issue of NAR.

68. Z. Yang, L. Shipman, M. Zhang, B. Anton, R.J. Roberts, X. Cheng (2004) Structural characterization and comparative phylogenetic analysis of E. coli HemK, a Protein (N5)-Glutamine Methyltransferase. J. Mol. Biol. 340, 695-706

67. A. Dong, L. Zhou, X. Zhang, S. Stickel, R.J. Roberts, X. Cheng (2004) Structure of the Q237W mutant of HhaI DNA methyltransferase: an insight into protein-protein interactions. Biological Chemistry 385, 373-379

66. Jackson JP, Johnson L, Jasencakova Z, Zhang X, PerezBurgos L, Singh PB, Cheng X, Schubert I, Jenuwein T, Jacobsen SE. (2004) Dimethylation of histone H3 lysine 9 is a critical mark for DNA methylation and gene silencing in Arabidopsis thaliana. Chromosoma. 112, 308-315

65. J.R. Horton, R.M. Blumenthal, X. Cheng (2004) Restriction endonucleases: structure of the conserved catalytic and the role of metal ions in DNA cleavage. In Restriction Endonucleases. Serius: Nucleic Acids and Molecular Biology, Pingoud, A. (ed.) Springer-Verlag Berlin Heidelberg. Vol. 14. pp 361-392

64. Z. Yang, J.R. Horton, L. Zhou, Xu Jia Zhang, A. Dong, Xing Zhang, S.L. Schlagman, V. Kossykh, S. Hattman, X. Cheng (2003) Structure of the bacteriophage T4 DNA adenine methyltransferase. Nature Struct. Biol. 10, 849-855

63. X. Zhang, Z Yang, S.I. Khan, J.R. Horton, H. Tamaru, E.U. Selker, X. Cheng (2003) Structural Basis for the Product Specificity of Histone Lysine Methyltransferases. Molecular Cell 12, 177-185
See preview by: R. N. Dutnall (2003) Cracking the histone codes: one, two, three methyls, you¡¯re out! Molecular Cell 12, 3-4

62. H. L. Schubert, R. M. Blumenthal, X. Cheng (2003) Many paths to methyltransfer: a chronicle of convergence. Trends Biochem. Sci. 28, 329-335

61. X. Zhang and X. Cheng (2003) Structure of the predominant protein arginine methyltransferase PRMT1 and analysis of its binding to substrate peptides. Structure 11, 509-520

60. H. Tamaru, X. Zhang, D. McMillen, P. Singh, J. Nakayama, S. I. Grewal, C. D. Allis, X. Cheng, E. U. Selker (2003) Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa. Nature Genetics, 34, 75-79

59. X. Cheng and R. J. Roberts (2003) MHhaI and Base flipping (an essay appears in Benjamin Lewin¡¯s web site at www.ergito.com submitted on 12/16/2002 and last revised on January 6, 2005)

58. P. Wu, C. Qiu, A. Sohail, X. Zhang, A. S. Bhagwat, X. Cheng (2003) Mismatch repair in methylated DNA: structure and activity of the mismatch-specific thymine glycosylase domain of methyl-CpG-binding protein MBD4. J. Biol. Chem. 278, 5285-5291

57. S. E. Whitehead, K. W. Jones, X. Zhang, X. Cheng, R. M. Terns, M. P. Terns (2002) Determinants of the interaction of the spinal muscular atrophy disease protein SMN with the dimethylarginine-modified box H/ACA small nucleolar ribonucleoprotein GAR1. J. Biol. Chem. 277, 48087-48093

56. R. M. Blumenthal and X. Cheng (2002) Restriction-Modification Systems. In Modern Microbial Genetics, 2nd edition (Yasbin R.E. and Streips U.N., eds.). New York: Wiley. ISBN 0-471-38665-0 657pp

55. J. Min, X. Zhang, X. Cheng, S. I. S. Grewal, R. Xu (2002) Structure of the SET domain histone lysine methyltransferase Clr4. Nature Struct. Biol. 9, 828-832

54. X. Zhang, H. Tamaru, S. I. Khan, J. R. Horton, L. J. Keefe, E. U. Selker, X. Cheng (2002) Structure of the Neurospora SET domain protein DIM-5, a histone H3 lysine methyltransferase. Cell 111, 117-127

53. L. Zhou, X. Cheng, B. A. Connolly, M. J. Dickman, P. J. Hurd, D. P. Hornby (2002) Zebularine: a novel DNA methylation inhibitor that forms a covalent complex with DNA methyltransferases. J. Mol. Biol. 321, 591-599

52. Y.-H. Lee, S.S. Koh, X. Zhang, X. Cheng and M.R. Stallcup (2002) Synergy among nuclear receptor coactivators: selective requirement for protein methyltransferase and acetyltransferase activities. Mol. Cell. Biol. 22, 3621-3632

51. X. Cheng and R.M. Blumenthal (2002) Cytosines do it, thymines do it, even pseudouridines do it ¨C base flipping by an enzyme that acts on RNA. Structure 10, 127-130

50. D.M. Green, K.A. Marfatia, E.B. Crafton, X. Zhang, X. Cheng, A.H. Corbett (2002) Nab2p is required for poly(A) RNA export in Saccharomyces cerevisiae and is regulated by arginine methylation via Hmt1p. J. Biol. Chem. 277, 7752-7760

49. C. Qiu, K. Sawada, X. Zhang, X. Cheng (2002) The PWWP domain of mammalian DNA methyltransferase Dnmt3b defines a new family of DNA-binding folds. Nature Struct. Biol. 9, 217-224

48. J.R. Horton, K. Sawada, M. Nishibori, X. Zhang, X. Cheng (2001) Two polymorphic forms of human histamine methyltransferase: structural, thermal and kinetic comparisons. Structure, 837-849
This paper was published as the cover story in the September 2001 issue of Structure.

47. J.C. Amor, J.R. Horton, X. Zhu, Y. Wong, C. Sullards, D. Ringe, X. Cheng, R.A. Kahn (2001) Structures of yeast ARF2 and ARL1: distinct roles for the N-terminus in the structure and function of ARF family GTPases. J. Biol. Chem. 276, 42477-42484                                                                                         

46. X. Cheng and R.J. Roberts (2001) AdoMet-dependent methylation, DNA methyltransferases, and base flipping. Nuclear Acids Res. 29, 3784-3795.

45. R. M. Blumenthal and X. Cheng (2001) A Taq attack displaces bases. Nature Struct. Biol. 8, 101-103

44. A. Dong, J. A. Yoder, L. Zhou, X. Zhang, T. Bestor, X. Cheng (2001) Structure of human DNMT2, an enigmatic DNA methyltransferase homologue that displays denaturant-resistant binding to DNA. Nucleic Acids Res. 29, 439-448

43. X. Cheng and R. J. Roberts (2000) Base flipping. Encyclopedia of Life Sciences / 2001 Nature Publishing Group / www.els.net (number of pages: 6)

42. G. Vilkaitis, A. Dong, E. Weinhold, X. Cheng, S. Klimasauskas (2000) Functional roles of the conserved threonine 250 in the target recognition domain of HhaI DNA methyltransferase. J. Biol. Chem. 275, 38722-38730

41. J. R. Horton and X. Cheng (2000) PvuII Endonuclease contains two calcium ions in active sites. J. Mol. Biol. 300, 1051-1058

40. X. Zhang, L. Zhou, X. Cheng (2000) Crystal structure of the conserved core of the protein arginine methyltransferase PRMT3. EMBO J. 19, 3509-3519

39. V. E. Marquez, A. Goddard, E. Alvarez, H. Ford Jr., J. K. Christman, G. Sheikhnejad, A. Brank, C. J. Marasco, J. R. Suffrin, M. O¡¯Gara, X. Cheng (1999) Oligonucleotides containing 5, 6-dihydro-5-azacytosine at CpG sites can produce potent inhibition of DNA cytosine-C5-methyltransferase without covalently binding to the enzyme. Antisense & Nucleic Acid Drug Development, 9, 415-421

38. E. B. Fauman, R. M. Blumenthal, X. Cheng (1999) Structure and evolution of AdoMet-dependent methyltransferases.  In X. Cheng and R. M. Blumenthal (eds.) AdoMet-dependent methyltransferases: structures and functions. (New Jersey: World Scientific. ISBN 981-02-3870-3 420pp) pp. 1-38

37. Y. Liu, W. Gong, C. C. Huang, W. Herr, X. Cheng (1999) Crystal structure of the conserved core of the HSV transcriptional regulatory protein VP16.  Genes & Dev. 13, 1692-1703

36. M. O¡¯Gara, X. Zhang, R. J. Roberts, X. Cheng (1999) Structure of a binary complex of HhaI methyltransferase with S-adenosyl-l-methionine formed in the presence of a short nonspecific DNA oligonucleotide. J. Mol. Biol. 287, 201-210

35. G. Sheikhnejad, A. Brank, J. K. Christman, A. Goddard, E. Alvarez, H. Ford, Jr., V. E. Marquez, C. J. Marasco, J. R. Sufrin, M. O¡¯Gara, X. Cheng (1999) Mechanism of inhibition of DNA-(cytosine C5) methyltransferases by oligodeoxyribonucleotides containing 5, 6-dihydro-5-azacytosine. J. Mol. Biol. 285, 2021-2034

34. J.R. Horton, H.G. Nastri, P.D. Riggs, X. Cheng (1998) Asp34 of PvuII endonuclease is directly involved in DNA minor groove recognition and indirectly involved in catalysis. J. Mol. Biol. 284, 1491-1504

33. J.R. Horton, J. Bonventre, X. Cheng (1998) How is modification of the DNA substrate recognized by the PvuII restriction endonuclease?  Biol. Chem. 379, 451-458

32. M. O¡¯Gara, J.R. Horton, R.J. Roberts, X. Cheng  (1998) Structures of HhaI methyltransferase complexed with substrates containing mismatches at the target base. Nature Struct. Biol. 5, 872-877

31. R.J. Roberts and X. Cheng (1998) Base flipping. Annu. Rev. Biochem. 67, 181-198

30. R.S. Lloyd and X. Cheng (1997) Mechanistic link between DNA methyltransferases and DNA repair enzymes by base flipping. Biopoly. 44, 139-151

29. S. Kumar, J.R. Horton, G. D. Jones, R. T. Walker, R. J. Roberts, X. Cheng (1997) DNA containing 4'-thio-2-deoxycytidine inhibits the methylation of HhaI methyltransferase. Nucleic Acids Res. 25, 2773-2783

28. W. Gong, M. O¡¯Gara, R.M. Blumenthal, X. Cheng (1997) Structure of PvuII DNA-(cytosine N4) methyltransferase, an example of domain permutation and protein fold assignment. Nucleic Acids Res. 25, 2702-2715. This paper was published as the cover story in the July 15, 1997 issue of Nucleic Acids Research.

27. M. O¡¯Gara, G. M. Adams, W. Gong, R. Kobayashi, R.M. Blumenthal, X. Cheng (1997) Expression, purification, masspectrometry, crystallization and multiwavelength anomalous diffraction of selenomethionyl PvuII DNA methyltransferase (cytosine-N4-specific). Eur J. Biochem. 247, 1009-1018

26. R. Xu, L. Jokhan, X. Cheng, A. Mayeda, A.R. Krainer (1997) Crystal structure of human UP1, the domain of hnRNP A1 that contains two RNA-recognition motifs.  Structure 5, 559-570

25. R. Xu, C. Koch, Y. Liu, J. R. Horton, D. Knapp, K. Nasmyth, X. Cheng (1997) Crystal structure of the DNA-binding domain of Mbp1, a transcription factor important in cell cycle control of DNA synthesis. Structure 5, 349-358

24. M. O¡¯Gara, R.J. Roberts, X. Cheng (1996) A structural basis for the preferential binding of hemimethylated DNA by HhaI DNA methyltransferase. J. Mol. Biol. 263, 597-606. This paper was published as the cover story in the November 8, 1996 issue of J. Mol. Biol.

23. M. O¡¯Gara, S. Klimasauskas, R.J. Roberts, X. Cheng (1996) Enzymatic C5-cytosine methylation of DNA: mechanistic implications of new crystal structures for HhaI methyltransferase-DNA-AdoHcy complexes. J. Mol. Biol.  261, 634-645. This paper was published as the cover story in the September 6, 1996 issue of J. Mol. Biol.

22. X. Cheng and R.M. Blumenthal (1996) Finding a basis for flipping bases. Structure 4, 639-645

21. R. Xu, G. Carmel, J. Kuret, X. Cheng (1996) Structural basis for selectivity of the isoquinoline sulfonamide family of protein kinase inhibitors. Proc. Natl. Acad. Sci. USA 93, 6308-6313

20. R. Xu, G. Carmel, R.M. Sweet, J. Kuret, X. Cheng (1995) Crystal structure of casein kinase-1, a phosphate-directed protein kinase. EMBO J. 14, 1015-1023
This paper was published as the cover story in the March 1, 1995 issue of EMBO J.

19. T. Malone, R.M. Blumenthal, X. Cheng (1995) Structure-guided analysis reveals nine sequence motifs conserved among DNA amino-methyltransferases, and suggests a catalytic mechanism for these enzymes. J. Mol. Biol. 253, 618-632

18. G. Schluckebier, M. O¡¯Gara, W. Saenger, X. Cheng (1995) Universal catalytic domain structure of AdoMet-dependent methyltransferases. J. Mol. Biol. 247, 16-20

17. X. Cheng (1995) Structure and function of DNA methyltransferases. Annu. Rev. Biophys. Biomol. Struct. 24, 293-31816.  

16. X. Cheng (1995) DNA modification by methyltransferases. Curr. Opin. Struc. Biol. 5, 4-10

15. X. Cheng, K.  Balendiran, I. Schildkraut, J. Anderson (1995) Crystal structure of the PvuII restriction endonuclease. Gene 157, 139-140

14. M. O¡¯Gara, K. McCloy, T. Malone, X. Cheng (1995) Structure-based sequence alignment of three AdoMet-dependent methyltransferases. Gene 157, 135-138

13. X. Cheng, K. Balendiran, I. Schildkraut, J. E. Anderson (1994) Structure of PvuII endonuclease with cognate DNA.  EMBO J. 13, 3927-3935

12. X. Cheng, X. Zhang, J. W. Pflugrath, F. W. Studier (1994) The structure of bacteriophage T7 lysozyme, a zinc amidase and an inhibitor of T7 RNA polymerase. Proc. Natl. Acad. Sci. USA 91, 4034-4038

11. G. Carmel, B. Leichus, X. Cheng, S. D. Patterson, U. Mirza, B. T. Chait, J. Kuret (1994) Expression, purification, crystallization, and preliminary X-ray analysis of casein kinase-1 from Schizosaccharomyces pombe. J. Biol. Chem. 269, 7304-7309

10. S. Kumar, X. Cheng, S. Klimasauskas, S. Mi, J. Posfai, R. J. Roberts, G. G. Wilson (1994) The DNA (cytosine-5) Methyltransferases. Nucleic Acids Res. 22, 1-10

9. S. Klimasauskas, S. Kumar, R. J. Roberts, X. Cheng (1994) HhaI methyltransferase flips its target base out of the DNA helix. Cell 76, 357-369
This paper was published as the cover story in the January 28, 1994 issue of Cell, and was honored as the cover of the journal Nucleic Acids Research throughout 1994.

8. X. Cheng, S. Kumar, S. Klimasauskas, R. J. Roberts (1993) Crystal structure of the HhaI DNA methyltransferase. Cold Spring Harbor Symp. Quan. Biol. 58, 331-338

7. X. Cheng, S. Kumar, J. Posfai, J. W. Pflugrath, R. J. Roberts (1993) Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-l-methionine. Cell 74, 299-307

6. S. Kumar, X. Cheng, J. W. Pflugrath, R. J. Roberts (1992). Purification, crystallization, and preliminary X-ray diffraction analysis of an M.HhaI-AdoMet complex. Biochemistry 31, 8648-8653

5. B. P. Schoenbom and X. Cheng (1991) The localization of solvent in protein crystals. In Protein: Structure, Dynamics and Design (ed. Renugopalakrishnan et al., ESCOM, Leiden) pp.  367-371

4. X. Cheng and B. P. Schoenbom (1991) Repulsive restraints for hydrogen bonding in least-squares refinement of protein crystals. Acta Cryst. A47, 314-317

3. X. Cheng and B. P. Schoenbom (1991) Neutron diffraction study of carbonmonoxymyoglobin. J. Mol. Biol.  220, 381-399

2. X. Cheng and B. P. Schoenbom (1990) Hydration in protein crystals. A neutron diffraction analysis of carbonmonoxymyoglobin. Acta Cryst.  B46, 195-208

1981 (Fudan University)

1. Z. Xu and X. Cheng (1981) The mass of neutrino and the Schwarzchild¡¯s internal solution when l not equal to 0¡±. Journal of Central China Normal University (Natural Sciences Edition, in Chinese), 2